Cigarette smoking, familial hematopoietic cancer, hair dye use, and risk of t(14;18)-defined subtypes of non-Hodgkin's lymphoma

Brian C H Chiu, Bhavana J Dave, Aaron Blair, Susan M. Gapstur, Joan S. Chmiel, Angela J. Fought, Shelia Hoar Zahm, Dennis D. Weisenburger

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Some evidence suggests that smoking, a family history of hematopoietic cancer, and use of hair dyes are associated with t(14;18)-defined subsets of non-Hodgkin's lymphoma (NHL) in men. To further evaluate these associations and to expand them to women, the authors determined t(14;18)(q32;q21) status by fluorescence in situ hybridization in 172 of 175 tumor blocks from a population-based case-control study conducted in Nebraska during 1983-1986. Exposures in 65 t(14;18)-positive cases and 107 t(14;18)-negative cases were compared with those among 1,432 controls. Odds ratios and 95% confidence intervals were calculated using polytomous logistic regression. Among men, smoking was not associated with risk of t(14;18)-positive or -negative NHL. Among women who had ever smoked cigarettes, there was an association with risk of t(14;18)-negative NHL (odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1, 3.3) but not t(14;18)-positive NHL (p-difference = 0.01). The risks for t(14;18)-negative NHL among women increased with longer duration (>30 years: OR = 2.1, 95% CI: 1.1, 4.1) and early initiation (age ≤20 years: OR = 2.2, 95% CI: 1.1, 4.4) of smoking. A family history of hematopoietic cancer was associated with a twofold higher risk for both t(14;18)-defined NHL subtypes among men and women. Hair dye use was not associated with either subtype. These findings should be interpreted cautiously because of the small sample.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalAmerican Journal of Epidemiology
Volume165
Issue number6
DOIs
StatePublished - Mar 1 2007

Fingerprint

Hair Dyes
Non-Hodgkin's Lymphoma
Smoking
Odds Ratio
Confidence Intervals
Neoplasms
Fluorescence In Situ Hybridization
Tobacco Products
Case-Control Studies
Logistic Models
Population

Keywords

  • Chromosome aberrations
  • Hair dyes
  • Hematologic neoplasms
  • Lymphoma, non-Hodgkin
  • Risk factors
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cigarette smoking, familial hematopoietic cancer, hair dye use, and risk of t(14;18)-defined subtypes of non-Hodgkin's lymphoma. / Chiu, Brian C H; Dave, Bhavana J; Blair, Aaron; Gapstur, Susan M.; Chmiel, Joan S.; Fought, Angela J.; Zahm, Shelia Hoar; Weisenburger, Dennis D.

In: American Journal of Epidemiology, Vol. 165, No. 6, 01.03.2007, p. 652-659.

Research output: Contribution to journalArticle

Chiu, Brian C H ; Dave, Bhavana J ; Blair, Aaron ; Gapstur, Susan M. ; Chmiel, Joan S. ; Fought, Angela J. ; Zahm, Shelia Hoar ; Weisenburger, Dennis D. / Cigarette smoking, familial hematopoietic cancer, hair dye use, and risk of t(14;18)-defined subtypes of non-Hodgkin's lymphoma. In: American Journal of Epidemiology. 2007 ; Vol. 165, No. 6. pp. 652-659.
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abstract = "Some evidence suggests that smoking, a family history of hematopoietic cancer, and use of hair dyes are associated with t(14;18)-defined subsets of non-Hodgkin's lymphoma (NHL) in men. To further evaluate these associations and to expand them to women, the authors determined t(14;18)(q32;q21) status by fluorescence in situ hybridization in 172 of 175 tumor blocks from a population-based case-control study conducted in Nebraska during 1983-1986. Exposures in 65 t(14;18)-positive cases and 107 t(14;18)-negative cases were compared with those among 1,432 controls. Odds ratios and 95{\%} confidence intervals were calculated using polytomous logistic regression. Among men, smoking was not associated with risk of t(14;18)-positive or -negative NHL. Among women who had ever smoked cigarettes, there was an association with risk of t(14;18)-negative NHL (odds ratio (OR) = 1.9, 95{\%} confidence interval (CI): 1.1, 3.3) but not t(14;18)-positive NHL (p-difference = 0.01). The risks for t(14;18)-negative NHL among women increased with longer duration (>30 years: OR = 2.1, 95{\%} CI: 1.1, 4.1) and early initiation (age ≤20 years: OR = 2.2, 95{\%} CI: 1.1, 4.4) of smoking. A family history of hematopoietic cancer was associated with a twofold higher risk for both t(14;18)-defined NHL subtypes among men and women. Hair dye use was not associated with either subtype. These findings should be interpreted cautiously because of the small sample.",
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