Cigarette smoke-induced pancreatic damage - Experimental data

Uwe A. Wittel, Ulrich T. Hopt, Surinder Kumar Batra

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background and aims: Epidemiological data clearly indicate that cigarette smoking is associated with an increased risk for developing chronic pancreatitis and pancreatic cancer. Despite of this clear epidemiological correlation, cigarette smoke-induced pancreatic damage has only been investigated in a small number of experimental studies. Methods: Experimental studies examining the effect of cigarette smoke or cigarette smoke constituents on the pancreas were reviewed. Results: Recent data indicate that smoking also induces chronic pancreatic inflammation in rodents within a period of 12 weeks upon exposure with environmental cigarette smoke. Supported by the finding that morphologic pancreatic damage is also induced by nicotine treatment, cigarette smoke-induced pancreatic damage is likely to be caused by a disturbance of regulation of exocrine pancreas. The morphological alterations, however, induced by nicotine, are less pronounced and therefore, other substances and pathophysiologic mechanisms, such as carcinogen action or cigarette smoke-induced reduction of anti-protease activity, are likely to aggravate pancreatic damage upon cigarette smoke inhalation. Conclusion: These data indicate that several constituents of cigarette smoke induce a disturbance of pancreatic function. This multifactorial event induces morphologic pancreatic damage upon cigarette smoke exposure in rodents.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalLangenbeck's Archives of Surgery
Volume393
Issue number4
DOIs
StatePublished - Jul 1 2008

Fingerprint

Smoke
Tobacco Products
Nicotine
Rodentia
Smoking
Exocrine Pancreas
Environmental Exposure
Chronic Pancreatitis
Pancreatic Neoplasms
Carcinogens
Inhalation
Pancreas
Peptide Hydrolases
Inflammation

Keywords

  • Carcinogen
  • Chronic pancreatitis
  • Cigarette smoking
  • Nicotine
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery

Cite this

Cigarette smoke-induced pancreatic damage - Experimental data. / Wittel, Uwe A.; Hopt, Ulrich T.; Batra, Surinder Kumar.

In: Langenbeck's Archives of Surgery, Vol. 393, No. 4, 01.07.2008, p. 581-588.

Research output: Contribution to journalArticle

Wittel, Uwe A. ; Hopt, Ulrich T. ; Batra, Surinder Kumar. / Cigarette smoke-induced pancreatic damage - Experimental data. In: Langenbeck's Archives of Surgery. 2008 ; Vol. 393, No. 4. pp. 581-588.
@article{d3a5a80d72d9403a9f299a001dbdea74,
title = "Cigarette smoke-induced pancreatic damage - Experimental data",
abstract = "Background and aims: Epidemiological data clearly indicate that cigarette smoking is associated with an increased risk for developing chronic pancreatitis and pancreatic cancer. Despite of this clear epidemiological correlation, cigarette smoke-induced pancreatic damage has only been investigated in a small number of experimental studies. Methods: Experimental studies examining the effect of cigarette smoke or cigarette smoke constituents on the pancreas were reviewed. Results: Recent data indicate that smoking also induces chronic pancreatic inflammation in rodents within a period of 12 weeks upon exposure with environmental cigarette smoke. Supported by the finding that morphologic pancreatic damage is also induced by nicotine treatment, cigarette smoke-induced pancreatic damage is likely to be caused by a disturbance of regulation of exocrine pancreas. The morphological alterations, however, induced by nicotine, are less pronounced and therefore, other substances and pathophysiologic mechanisms, such as carcinogen action or cigarette smoke-induced reduction of anti-protease activity, are likely to aggravate pancreatic damage upon cigarette smoke inhalation. Conclusion: These data indicate that several constituents of cigarette smoke induce a disturbance of pancreatic function. This multifactorial event induces morphologic pancreatic damage upon cigarette smoke exposure in rodents.",
keywords = "Carcinogen, Chronic pancreatitis, Cigarette smoking, Nicotine, Pancreatic cancer",
author = "Wittel, {Uwe A.} and Hopt, {Ulrich T.} and Batra, {Surinder Kumar}",
year = "2008",
month = "7",
day = "1",
doi = "10.1007/s00423-007-0273-3",
language = "English (US)",
volume = "393",
pages = "581--588",
journal = "Langenbeck's Archives of Surgery",
issn = "1435-2443",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Cigarette smoke-induced pancreatic damage - Experimental data

AU - Wittel, Uwe A.

AU - Hopt, Ulrich T.

AU - Batra, Surinder Kumar

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Background and aims: Epidemiological data clearly indicate that cigarette smoking is associated with an increased risk for developing chronic pancreatitis and pancreatic cancer. Despite of this clear epidemiological correlation, cigarette smoke-induced pancreatic damage has only been investigated in a small number of experimental studies. Methods: Experimental studies examining the effect of cigarette smoke or cigarette smoke constituents on the pancreas were reviewed. Results: Recent data indicate that smoking also induces chronic pancreatic inflammation in rodents within a period of 12 weeks upon exposure with environmental cigarette smoke. Supported by the finding that morphologic pancreatic damage is also induced by nicotine treatment, cigarette smoke-induced pancreatic damage is likely to be caused by a disturbance of regulation of exocrine pancreas. The morphological alterations, however, induced by nicotine, are less pronounced and therefore, other substances and pathophysiologic mechanisms, such as carcinogen action or cigarette smoke-induced reduction of anti-protease activity, are likely to aggravate pancreatic damage upon cigarette smoke inhalation. Conclusion: These data indicate that several constituents of cigarette smoke induce a disturbance of pancreatic function. This multifactorial event induces morphologic pancreatic damage upon cigarette smoke exposure in rodents.

AB - Background and aims: Epidemiological data clearly indicate that cigarette smoking is associated with an increased risk for developing chronic pancreatitis and pancreatic cancer. Despite of this clear epidemiological correlation, cigarette smoke-induced pancreatic damage has only been investigated in a small number of experimental studies. Methods: Experimental studies examining the effect of cigarette smoke or cigarette smoke constituents on the pancreas were reviewed. Results: Recent data indicate that smoking also induces chronic pancreatic inflammation in rodents within a period of 12 weeks upon exposure with environmental cigarette smoke. Supported by the finding that morphologic pancreatic damage is also induced by nicotine treatment, cigarette smoke-induced pancreatic damage is likely to be caused by a disturbance of regulation of exocrine pancreas. The morphological alterations, however, induced by nicotine, are less pronounced and therefore, other substances and pathophysiologic mechanisms, such as carcinogen action or cigarette smoke-induced reduction of anti-protease activity, are likely to aggravate pancreatic damage upon cigarette smoke inhalation. Conclusion: These data indicate that several constituents of cigarette smoke induce a disturbance of pancreatic function. This multifactorial event induces morphologic pancreatic damage upon cigarette smoke exposure in rodents.

KW - Carcinogen

KW - Chronic pancreatitis

KW - Cigarette smoking

KW - Nicotine

KW - Pancreatic cancer

UR - http://www.scopus.com/inward/record.url?scp=43149113030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43149113030&partnerID=8YFLogxK

U2 - 10.1007/s00423-007-0273-3

DO - 10.1007/s00423-007-0273-3

M3 - Article

C2 - 18193450

AN - SCOPUS:43149113030

VL - 393

SP - 581

EP - 588

JO - Langenbeck's Archives of Surgery

JF - Langenbeck's Archives of Surgery

SN - 1435-2443

IS - 4

ER -