Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Jing Zhen Deng, A. Sun Di-An, Shelley R. Starck, Sidney M. Hecht, Ronald Cerny, John R. Engen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 μM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl /n-methylhydroquinone occurring in a higher terrestrial plant.

Original languageEnglish (US)
Pages (from-to)1147-1149
Number of pages3
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number9
DOIs
StatePublished - Jan 1 1999

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Hydroquinones
Nucleic Acid Synthesis Inhibitors
Bioassay
Diterpenes
DNA-Directed DNA Polymerase
Fractionation
Acids
prenyl

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β. / Deng, Jing Zhen; Sun Di-An, A.; Starck, Shelley R.; Hecht, Sidney M.; Cerny, Ronald; Engen, John R.

In: Journal of the Chemical Society - Perkin Transactions 1, No. 9, 01.01.1999, p. 1147-1149.

Research output: Contribution to journalArticle

Deng, Jing Zhen ; Sun Di-An, A. ; Starck, Shelley R. ; Hecht, Sidney M. ; Cerny, Ronald ; Engen, John R. / Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β. In: Journal of the Chemical Society - Perkin Transactions 1. 1999 ; No. 9. pp. 1147-1149.
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