Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice

Lora L Arnold, Michal Eldan, Marcia Van Gemert, Charles C. Capen, Samuel Monroe Cohen

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Abstract

Monomethylarsonic acid (MMA) was administered in the diet of male and female Fischer F344 rats and B6C3F1 mice in 2-year feeding studies according to US EPA guidelines. Rats were treated with 50, 400, or 1300 ppm MMA and mice were treated with 10, 50, 200, or 400 ppm MMA based on preliminary short-term studies. The highest dose in the male and female rat groups was reduced to 1000 ppm during week 53 and then further reduced to 800 ppm during week 60 due to high mortality in the male rats. There was no treatment-related mortality in the mice. The primary target organ for MMA-induced toxicity in rats and mice was the large intestine. Toxicity was more severe in rats compared to mice and in male rats compared to female rats. The maximum tolerated dose for chronic dietary administration of MMA in rats and mice was assessed as 400 ppm, and the no effect level with regard to intestinal toxicity was assessed as 50 ppm for rats and female mice and 200 ppm for male mice. There were no treatment-related neoplastic effects detected in either the rat or the mouse.

Original languageEnglish (US)
Pages (from-to)197-219
Number of pages23
JournalToxicology
Volume190
Issue number3
DOIs
StatePublished - Aug 28 2003

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Rats
Toxicity
Inbred F344 Rats
monomethylarsonic acid
Maximum Tolerated Dose
Mortality
Large Intestine
Nutrition
Guidelines
Diet

Keywords

  • Carcinogenicity
  • Chronic toxicity
  • Large intestine
  • Monomethylarsonic acid

ASJC Scopus subject areas

  • Toxicology

Cite this

Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice. / Arnold, Lora L; Eldan, Michal; Van Gemert, Marcia; Capen, Charles C.; Cohen, Samuel Monroe.

In: Toxicology, Vol. 190, No. 3, 28.08.2003, p. 197-219.

Research output: Contribution to journalArticle

Arnold, Lora L ; Eldan, Michal ; Van Gemert, Marcia ; Capen, Charles C. ; Cohen, Samuel Monroe. / Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice. In: Toxicology. 2003 ; Vol. 190, No. 3. pp. 197-219.
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