Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma

Skylar Alsop, Warren G Sanger, Kojo S.J. Elenitoba-Johnson, Megan S. Lim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The development of Philadelphia chromosome-positive chronic myelogenous leukemia (CML) in the adolescent population is very rare. CML occurring as a secondary malignancy in individuals treated for anaplastic large cell lymphoma (ALCL) is also rare. We present the case of a 16-year-old adolescent boy who developed a right orbital mass that was diagnosed as ALCL with the t(2;5)(p23;q25) chromosomal aberration. Four years after receiving treatment for ALCL, he presented with a swollen leg and a white cell count of 431 000. Peripheral blood and bone marrow evaluation revealed a myeloproliferative disorder. Cytogenetic and molecular studies demonstrated the presence of t(9;22). We present the histopathologic, molecular, and cytogenetic findings of this patient's initial presentation with systemic ALCL as well as his secondary presentation with CML 4 years later. Therapy-related CML and non-therapy-related secondary CML are discussed as potential explanations of this highly unusual clinical presentation.

Original languageEnglish (US)
Pages (from-to)1576-1580
Number of pages5
JournalHuman Pathology
Volume38
Issue number10
DOIs
StatePublished - Oct 1 2007

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Anaplastic Large-Cell Lymphoma
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neoplasms
Cytogenetics
Philadelphia Chromosome
Myeloproliferative Disorders
Chromosome Aberrations
Leg
Cell Count
Bone Marrow
Therapeutics
Population

Keywords

  • Anaplastic large cell lymphoma
  • Chronic myeloid leukemia
  • Therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma. / Alsop, Skylar; Sanger, Warren G; Elenitoba-Johnson, Kojo S.J.; Lim, Megan S.

In: Human Pathology, Vol. 38, No. 10, 01.10.2007, p. 1576-1580.

Research output: Contribution to journalArticle

Alsop, Skylar ; Sanger, Warren G ; Elenitoba-Johnson, Kojo S.J. ; Lim, Megan S. / Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma. In: Human Pathology. 2007 ; Vol. 38, No. 10. pp. 1576-1580.
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