Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

N. Osna, G. Silonova, N. Vilgert, E. Hagina, V. Kuse, V. Giedraitis, A. Zvirbliene, M. Mauricas, A. Sochnev

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

Original languageEnglish (US)
Pages (from-to)703-710
Number of pages8
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume57
Issue number8
DOIs
StatePublished - Jan 1 1997

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Chronic Hepatitis C
Viruses
Interleukin-10
Interferon-gamma
Blood
Interleukin-12
Interleukin-4
Mitogens
Blood Cells
Tissue Donors

Keywords

  • Chronic hepatitis C
  • Interferon gamma
  • Interleukin 10
  • Interleukin 12
  • Interleukin 4

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Chronic hepatitis C : T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. / Osna, N.; Silonova, G.; Vilgert, N.; Hagina, E.; Kuse, V.; Giedraitis, V.; Zvirbliene, A.; Mauricas, M.; Sochnev, A.

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 57, No. 8, 01.01.1997, p. 703-710.

Research output: Contribution to journalArticle

Osna, N, Silonova, G, Vilgert, N, Hagina, E, Kuse, V, Giedraitis, V, Zvirbliene, A, Mauricas, M & Sochnev, A 1997, 'Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 57, no. 8, pp. 703-710. https://doi.org/10.3109/00365519709105232
Osna, N. ; Silonova, G. ; Vilgert, N. ; Hagina, E. ; Kuse, V. ; Giedraitis, V. ; Zvirbliene, A. ; Mauricas, M. ; Sochnev, A. / Chronic hepatitis C : T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. In: Scandinavian Journal of Clinical and Laboratory Investigation. 1997 ; Vol. 57, No. 8. pp. 703-710.
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