Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure

Irving H Zucker, Johnnie F. Hackley, Kurtis G. Cornish, Bradley A. Hiser, Nicholas R. Anderson, Robert Kieval, Eric D. Irwin, David J. Serdar, Jacob D. Peuler, Martin A. Rossing

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Much of the current pharmacological therapy for chronic heart failure targets neurohormonal activation. In spite of recent advances in drug therapy, the mortality rate for chronic heart failure remains high. Activation of the carotid baroreceptor (BR) reduces sympathetic outflow and augments vagal tone. We investigated the effect of chronic activation of the carotid BR on hemodynamic and neurohormonal parameters and on mortality in dogs with chronic heart failure. Fifteen dogs were instrumented to record hemodynamics. Electrodes were applied around the carotid sinuses to allow for activation of the BR. After 2 weeks of pacing (250 bpm), electrical carotid BR activation was initiated in 7 dogs and continued for the remainder of the study. The start of BR activation was used as a time reference point for the remaining 8 control dogs that did not receive BR activation. Survival was significantly greater for dogs undergoing carotid BR activation compared with control dogs (68.1±7.4 versus 37.3±3.2 days, respectively; P<0.01), although arterial pressure, resting heart rate, and left ventricular pressure were not different over time in BR-activated versus control dogs. Plasma norepinephrine was lower in dogs receiving BR activation therapy 31 days after the start of BR activation (401.9±151.5 versus 1121.9±389.1 pg/mL in dogs not receiving activation therapy; P<0.05). Plasma angiotensin II increased less in dogs receiving activation therapy (plasma angiotensin II increased by 157.4±58.6 pg/mL in control dogs versus 10.1±14.0 pg/mL in dogs receiving activation therapy; P<0.02). We conclude that chronic activation of the carotid BR improves survival and suppresses neurohormonal activation in chronic heart failure.

Original languageEnglish (US)
Pages (from-to)904-910
Number of pages7
JournalHypertension
Volume50
Issue number5
DOIs
StatePublished - Nov 1 2007

Fingerprint

Pressoreceptors
Heart Failure
Dogs
Angiotensin II
Hemodynamics
Therapeutics
Carotid Sinus
Mortality
Ventricular Pressure
Norepinephrine
Arterial Pressure
Electrodes
Heart Rate

Keywords

  • Baroreflex
  • Carotid sinus
  • Nerve stimulation
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Zucker, I. H., Hackley, J. F., Cornish, K. G., Hiser, B. A., Anderson, N. R., Kieval, R., ... Rossing, M. A. (2007). Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. Hypertension, 50(5), 904-910. https://doi.org/10.1161/HYPERTENSIONAHA.107.095216

Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. / Zucker, Irving H; Hackley, Johnnie F.; Cornish, Kurtis G.; Hiser, Bradley A.; Anderson, Nicholas R.; Kieval, Robert; Irwin, Eric D.; Serdar, David J.; Peuler, Jacob D.; Rossing, Martin A.

In: Hypertension, Vol. 50, No. 5, 01.11.2007, p. 904-910.

Research output: Contribution to journalArticle

Zucker, IH, Hackley, JF, Cornish, KG, Hiser, BA, Anderson, NR, Kieval, R, Irwin, ED, Serdar, DJ, Peuler, JD & Rossing, MA 2007, 'Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure', Hypertension, vol. 50, no. 5, pp. 904-910. https://doi.org/10.1161/HYPERTENSIONAHA.107.095216
Zucker, Irving H ; Hackley, Johnnie F. ; Cornish, Kurtis G. ; Hiser, Bradley A. ; Anderson, Nicholas R. ; Kieval, Robert ; Irwin, Eric D. ; Serdar, David J. ; Peuler, Jacob D. ; Rossing, Martin A. / Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. In: Hypertension. 2007 ; Vol. 50, No. 5. pp. 904-910.
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AU - Anderson, Nicholas R.

AU - Kieval, Robert

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