Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques

Maria Cecilia G. Marcondes, Debbie Watry, Michelle Zandonatti, Claudia Flynn, Michael A. Taffe, Howard S Fox

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Alcohol consumption is a common problem in HIV-infected individuals, and the effects of alcohol may alter the efficiency of the immune response, potentially aggravating the disease as well as affecting end organs, such as the brain. However, the elements of the virus-host interaction that are modulated by ethanol are poorly dissected. Methods: Ethanol intake was conditioned in rhesus macaques prior to SIV infection, in order to mimic this common human behavior, and allow the evaluation of aspects of the virus-immune system interactions during acute time-points, when important facets of the infection are set up and when virus reproducibly enters the brain. Results: Although ethanol had a limited effect on the acute plasma viral load, it resulted in reduced circulating memory CD4+ T cells and increased levels of monocytes expressing the viral coreceptor CCR5. In organs, ethanol consumption impacted immune cells in the liver as well as lymphoid and other nonlymphoid tissues, where CD4+ T cells were predominantly affected. Conclusion: Overall, the consumption of alcohol causes immune cell alterations that can contribute to the generation of a disease susceptible environment upon SIV infection.

Original languageEnglish (US)
Pages (from-to)1583-1592
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume32
Issue number9
DOIs
StatePublished - Sep 1 2008

Fingerprint

Macaca mulatta
Alcohol Drinking
Ethanol
Viruses
Alcohols
T-cells
Infection
Brain
T-Lymphocytes
Immune system
Viral Load
Liver
Monocytes
Immune System
HIV
Tissue
Plasmas
Data storage equipment

Keywords

  • Acute phase
  • Alcohol
  • CCR5
  • HIV
  • Memory CD4 cells
  • SIV

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques. / Marcondes, Maria Cecilia G.; Watry, Debbie; Zandonatti, Michelle; Flynn, Claudia; Taffe, Michael A.; Fox, Howard S.

In: Alcoholism: Clinical and Experimental Research, Vol. 32, No. 9, 01.09.2008, p. 1583-1592.

Research output: Contribution to journalArticle

Marcondes, Maria Cecilia G. ; Watry, Debbie ; Zandonatti, Michelle ; Flynn, Claudia ; Taffe, Michael A. ; Fox, Howard S. / Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques. In: Alcoholism: Clinical and Experimental Research. 2008 ; Vol. 32, No. 9. pp. 1583-1592.
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