Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice

Yiu K. Fung, Lori A. Fiske, Yuen Sum Lau

Research output: Contribution to journalArticle

17 Scopus citations


1. 1. The effects of chronic (14 day) administration of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (15 mg/kg, s.c.)-induced neurotoxicity in C57BL/6 mice were examined. 2. 2. Nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by MPTP. 3. 3. Our results do not support a therapeutic action of nicotine in a Parkinsonian animal model.

Original languageEnglish (US)
Pages (from-to)669-672
Number of pages4
JournalGeneral Pharmacology
Issue number4
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Pharmacology

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