Chromosome damaging effects of pan masala

R. J. Jaju, R. K. Patel, S. R. Bakshi, A. H. Trivedi, B. J. Dave, S. G. Adhvaryu

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23 Scopus citations

Abstract

Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in supression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalCancer Letters
Volume65
Issue number3
DOIs
StatePublished - Aug 31 1992

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Keywords

  • aqueous extract
  • chromosome aberration
  • micronucleus
  • pan masala
  • sister chromatid exchange

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jaju, R. J., Patel, R. K., Bakshi, S. R., Trivedi, A. H., Dave, B. J., & Adhvaryu, S. G. (1992). Chromosome damaging effects of pan masala. Cancer Letters, 65(3), 221-226. https://doi.org/10.1016/0304-3835(92)90235-N