Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas

Bhavana J Dave, Rakesh K Singh, Isaiah J. Fidler, Sen Pathak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to correlate abnormalities in chromosome 14 with the invasive metastatic phenotype of K-1735 murine melanoma cells. Low metastatic K-1735 clone 10 and clone 23 cells were transfected with either basic fibroblast growth factor (bFGF), Kaposi's fibroblast growth factor (kFGF), or c-H-ras gene. A high number of bFGF- and H-ras-transfected cells exhibited chromosome 14 rearrangements. These cells also had increased expression of collagenase IV. The kFGF transfected cells were highly metastatic but did not have increased expression of collagenase type IV, nor abnormalities in chromosome 14. The data imply that karyotypic changes in chromosome 14 are associated with increase expression of collagenase type IV.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalCancer genetics and cytogenetics
Volume92
Issue number1
DOIs
StatePublished - Nov 1 1997

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Chromosomes, Human, Pair 14
Collagenases
Melanoma
Fibroblast Growth Factors
Fibroblast Growth Factor 2
Clone Cells
Complement Factor H
ras Genes
Phenotype

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas. / Dave, Bhavana J; Singh, Rakesh K; Fidler, Isaiah J.; Pathak, Sen.

In: Cancer genetics and cytogenetics, Vol. 92, No. 1, 01.11.1997, p. 66-72.

Research output: Contribution to journalArticle

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