Chromosomal abnormalities in patients with non-cutaneous T-cell non-Hodgkin's lymphoma

Harry C. Schouten, Warren G. Sanger, Dennis D. Weisenburger, James Olen Armitage

Research output: Contribution to journalArticle

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Abstract

In contrast to non-Hodgkin's lymphomas (NHL) with a B-cell phenotype, almost no data have been reported dealing with correlations between chromosomal abnormalities and characteristics of the disease in patients with T-cell NHL. In a retrospective analysis we studied all patients with a non-cutaneous T-cell NHL and chromosomal abnormalities that were evaluated at our institution; 20 patients could be identified. Numerical abnormalities involving chromosomes 3, 4, 5, 22 and X were observed most frequently. Structural abnormalities involved mainly the breakpoints 1q22-25, 6q23 and 11q13. There appeared to be an association between +7 breakpoints 2p23-24, 4p14-15, 8q21 and the presence of extranodal disease. All patients with +7 had a diffuse mixed histology. Patients with +2, +3, +11, +17, +18, +20 or breakpoint 1q22-25 had an immunoblastic lymphoma and patients with breakpoints 9q32-34 or 14q12 had a lymphoblastic lymphoma. No correlations were observed between chromosomal abnormalities and response to therapy, survival or phenotypic markers. Abnormalities involving the chromosomes containing the T-cell receptor genes and T-cell markers were infrequent. Several breakpoints were identified that correlate with already described oncogenes.

Original languageEnglish (US)
Pages (from-to)618-622
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1990

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Chromosome Aberrations
Non-Hodgkin's Lymphoma
T-Lymphocytes
T-Cell Receptor Genes
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 3
T-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Oncogenes
Lymphoma
Histology
B-Lymphocytes
Phenotype
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Chromosomal abnormalities in patients with non-cutaneous T-cell non-Hodgkin's lymphoma. / Schouten, Harry C.; Sanger, Warren G.; Weisenburger, Dennis D.; Armitage, James Olen.

In: European Journal of Cancer and Clinical Oncology, Vol. 26, No. 5, 01.01.1990, p. 618-622.

Research output: Contribution to journalArticle

Schouten, Harry C. ; Sanger, Warren G. ; Weisenburger, Dennis D. ; Armitage, James Olen. / Chromosomal abnormalities in patients with non-cutaneous T-cell non-Hodgkin's lymphoma. In: European Journal of Cancer and Clinical Oncology. 1990 ; Vol. 26, No. 5. pp. 618-622.
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