Chromosomal abnormalities in Hodgkin's disease

H. C. Schouten, W. G. Sanger, M. Duggan, D. D. Wiesenburger, K. A. MacLennan, James Olen Armitage

Research output: Contribution to journalArticle

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Abstract

Numerous neoplastic states have associated or causal cytogenetic abnormalities. In some cancers, specific chromosomal abnormalities appear to correlate with the clinical characteristics and prognosis. Cytogenetic analysis of Hodgkin's disease is thought to be technically difficult and only a small number of cases with evaluable results have been reported. We have attempted cytogenetic studies of lymph nodes from 37 patients with Hodgkin's disease. In 29 of the 37 patients (78%), successful chromosomal analysis was accomplished. Chromosomal abnormalities were found in 13 patients (45%); five of these patients had been previously treated with chemotherapy. Numerical changes were found in all patients, most commonly involving chromosomes 5, 9, 15, 18, 22, X, and marker chromosomes. Seven patients also had structural abnormalities. The breakpoints 4q32-34, 6q24, 12q13, 12q23-24, and 13p11-13 were each seen in at least two patients. All but two patients had an admixture of normal cells. Three patients had two or more clones, and one had subclones. No statistically significant correlations between chromosomal abnormalities and clinical characteristics were demonstrated, although the number of patients in each subgroup was small. We conclude that chromosomal studies of Hodgkin's disease are likely to be successful. Additional studies are needed to correlate the karyotypical abnormalities in Hodgkin's disease with clinical and biological characteristics.

Original languageEnglish (US)
Pages (from-to)2149-2154
Number of pages6
JournalBlood
Volume73
Issue number8
StatePublished - Jan 1 1989

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Hodgkin Disease
Chromosome Aberrations
Chromosomes
Chemotherapy
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 5
Cytogenetic Analysis
X Chromosome
Cytogenetics
Clone Cells
Lymph Nodes
Drug Therapy

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Schouten, H. C., Sanger, W. G., Duggan, M., Wiesenburger, D. D., MacLennan, K. A., & Armitage, J. O. (1989). Chromosomal abnormalities in Hodgkin's disease. Blood, 73(8), 2149-2154.

Chromosomal abnormalities in Hodgkin's disease. / Schouten, H. C.; Sanger, W. G.; Duggan, M.; Wiesenburger, D. D.; MacLennan, K. A.; Armitage, James Olen.

In: Blood, Vol. 73, No. 8, 01.01.1989, p. 2149-2154.

Research output: Contribution to journalArticle

Schouten, HC, Sanger, WG, Duggan, M, Wiesenburger, DD, MacLennan, KA & Armitage, JO 1989, 'Chromosomal abnormalities in Hodgkin's disease', Blood, vol. 73, no. 8, pp. 2149-2154.
Schouten HC, Sanger WG, Duggan M, Wiesenburger DD, MacLennan KA, Armitage JO. Chromosomal abnormalities in Hodgkin's disease. Blood. 1989 Jan 1;73(8):2149-2154.
Schouten, H. C. ; Sanger, W. G. ; Duggan, M. ; Wiesenburger, D. D. ; MacLennan, K. A. ; Armitage, James Olen. / Chromosomal abnormalities in Hodgkin's disease. In: Blood. 1989 ; Vol. 73, No. 8. pp. 2149-2154.
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