Chromatin remodeling

A novel mechanism of psychotropic drug action

Samuel Sathyanesan, Ronald S. Duman

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalMolecular pharmacology
Volume70
Issue number2
DOIs
StatePublished - Jul 26 2006

Fingerprint

Chromatin Assembly and Disassembly
Psychotropic Drugs
Gene Expression Regulation
Street Drugs
Acetylation
Histones
Antidepressive Agents
Chromatin
Carrier Proteins
Pharmacology
Gene Expression
Genes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Chromatin remodeling : A novel mechanism of psychotropic drug action. / Sathyanesan, Samuel; Duman, Ronald S.

In: Molecular pharmacology, Vol. 70, No. 2, 26.07.2006, p. 440-443.

Research output: Contribution to journalReview article

@article{83d55bb8b7a5440da0fae218c0a44b6a,
title = "Chromatin remodeling: A novel mechanism of psychotropic drug action",
abstract = "Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression.",
author = "Samuel Sathyanesan and Duman, {Ronald S.}",
year = "2006",
month = "7",
day = "26",
doi = "10.1124/mol.106.027078",
language = "English (US)",
volume = "70",
pages = "440--443",
journal = "Molecular Pharmacology",
issn = "0026-895X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "2",

}

TY - JOUR

T1 - Chromatin remodeling

T2 - A novel mechanism of psychotropic drug action

AU - Sathyanesan, Samuel

AU - Duman, Ronald S.

PY - 2006/7/26

Y1 - 2006/7/26

N2 - Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression.

AB - Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression.

UR - http://www.scopus.com/inward/record.url?scp=33746217425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746217425&partnerID=8YFLogxK

U2 - 10.1124/mol.106.027078

DO - 10.1124/mol.106.027078

M3 - Review article

VL - 70

SP - 440

EP - 443

JO - Molecular Pharmacology

JF - Molecular Pharmacology

SN - 0026-895X

IS - 2

ER -