Cholestasis of sepsis

Richard K. Gilroy, Mark E Mailliard, John L. Gollan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without direct bacterial involvement of the biliary system and appears to be mediated systemically by pro-inflammatory cytokines. These cytokines are released in response to the vigorous inflammatory reaction mediated by endotoxinaemia and bacterial wall lipopolysaccharides. The principal cytokines involved are the pro-inflammatory tumour necrosis factor-alpha (TNF-α), interleukin (IL) 1-β and IL-6. Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. Management principles focus upon the control of sepsis.

Original languageEnglish (US)
Pages (from-to)357-367
Number of pages11
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Volume17
Issue number3
DOIs
StatePublished - Jun 1 2003

Fingerprint

Cholestasis
Sepsis
Cytokines
Membrane Transport Proteins
Biliary Tract
Interleukin-1
Lipopolysaccharides
Hepatocytes
Interleukin-6
Tumor Necrosis Factor-alpha

Keywords

  • Cholestasis
  • Cytokines
  • Endotoxin
  • Hepatocyte transporters
  • Lipopolysaccharides
  • Sepsis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cholestasis of sepsis. / Gilroy, Richard K.; Mailliard, Mark E; Gollan, John L.

In: Bailliere's Best Practice and Research in Clinical Gastroenterology, Vol. 17, No. 3, 01.06.2003, p. 357-367.

Research output: Contribution to journalArticle

Gilroy, Richard K. ; Mailliard, Mark E ; Gollan, John L. / Cholestasis of sepsis. In: Bailliere's Best Practice and Research in Clinical Gastroenterology. 2003 ; Vol. 17, No. 3. pp. 357-367.
@article{4b955e94cda64b0884892aec9d32f7b7,
title = "Cholestasis of sepsis",
abstract = "Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without direct bacterial involvement of the biliary system and appears to be mediated systemically by pro-inflammatory cytokines. These cytokines are released in response to the vigorous inflammatory reaction mediated by endotoxinaemia and bacterial wall lipopolysaccharides. The principal cytokines involved are the pro-inflammatory tumour necrosis factor-alpha (TNF-α), interleukin (IL) 1-β and IL-6. Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. Management principles focus upon the control of sepsis.",
keywords = "Cholestasis, Cytokines, Endotoxin, Hepatocyte transporters, Lipopolysaccharides, Sepsis",
author = "Gilroy, {Richard K.} and Mailliard, {Mark E} and Gollan, {John L.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S1521-6918(03)00027-1",
language = "English (US)",
volume = "17",
pages = "357--367",
journal = "Bailliere's Best Practice and Research in Clinical Gastroenterology",
issn = "1521-6918",
publisher = "Bailliere Tindall Ltd",
number = "3",

}

TY - JOUR

T1 - Cholestasis of sepsis

AU - Gilroy, Richard K.

AU - Mailliard, Mark E

AU - Gollan, John L.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without direct bacterial involvement of the biliary system and appears to be mediated systemically by pro-inflammatory cytokines. These cytokines are released in response to the vigorous inflammatory reaction mediated by endotoxinaemia and bacterial wall lipopolysaccharides. The principal cytokines involved are the pro-inflammatory tumour necrosis factor-alpha (TNF-α), interleukin (IL) 1-β and IL-6. Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. Management principles focus upon the control of sepsis.

AB - Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without direct bacterial involvement of the biliary system and appears to be mediated systemically by pro-inflammatory cytokines. These cytokines are released in response to the vigorous inflammatory reaction mediated by endotoxinaemia and bacterial wall lipopolysaccharides. The principal cytokines involved are the pro-inflammatory tumour necrosis factor-alpha (TNF-α), interleukin (IL) 1-β and IL-6. Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. Management principles focus upon the control of sepsis.

KW - Cholestasis

KW - Cytokines

KW - Endotoxin

KW - Hepatocyte transporters

KW - Lipopolysaccharides

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=0141688070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141688070&partnerID=8YFLogxK

U2 - 10.1016/S1521-6918(03)00027-1

DO - 10.1016/S1521-6918(03)00027-1

M3 - Article

VL - 17

SP - 357

EP - 367

JO - Bailliere's Best Practice and Research in Clinical Gastroenterology

JF - Bailliere's Best Practice and Research in Clinical Gastroenterology

SN - 1521-6918

IS - 3

ER -