Cholecystokinin-induced gastroprotection: A review of current protective mechanisms

Sonlee D. West, David W. Mercer

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Cholecystokinin (CCK) is a member of a family of gastrointestinal peptides known to physiologically regulate pancreatic protein secretion, gallbladder contractility, and gut motility. In addition, CCK has been found to play important roles in endocrine and neural systems in the periphery as well as in the central nervous system. CCK has been proposed to play a role in satiety, anxiety, and intestinal transit in addition to its well-described effects in coordinating digestion of a meal. We and others have shown that exogenous and endogenous CCK prevent gastric injury from luminal irritants. These data suggest that the release of CCK may represent an important component of the intrinsic gastric mucosal defense system. This review focuses on the ability of CCK to render the stomach more resistant to injury from luminal insults and will summarize recent studies that examine the possible mechanisms involved.

Original languageEnglish (US)
Pages (from-to)361-369
Number of pages9
JournalDigestive Diseases and Sciences
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2004

Fingerprint

Cholecystokinin
Stomach
Endocrine System
Aptitude
Irritants
Wounds and Injuries
Gallbladder
Meals
Digestion
Anxiety
Central Nervous System
Peptides
Proteins

Keywords

  • Gastric injury
  • Mild irritants
  • Nitric oxide
  • Prostaglandins
  • Sensory neurons

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Cholecystokinin-induced gastroprotection : A review of current protective mechanisms. / West, Sonlee D.; Mercer, David W.

In: Digestive Diseases and Sciences, Vol. 49, No. 3, 01.03.2004, p. 361-369.

Research output: Contribution to journalReview article

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