Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis

Fei Yu, Ying Xie, Yan Wang, Zheng Hong Peng, Jing Li, David Oupicky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chloroquine-containing HPMA copolymers (pCQs) were synthesized for the first time by copolymerization of methacryloylated hydroxychloroquine and HPMA. The copolymers showed lower cytotoxicity when compared with hydroxychloroquine. Treatment of cancer cells with pCQ resulted in decreased surface expression of chemokine receptor CXCR4. The pCQ copolymers showed effective inhibition of CXCR4/SDF1-mediated cancer cell migration that was fully comparable with a commercial small-molecule CXCR4 antagonist AMD3100. The reported pCQ represent unique and simple polymeric drugs with potential use as part of a combination antimetastatic therapies. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalACS Macro Letters
Volume5
Issue number3
DOIs
StatePublished - Mar 15 2016

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hydroxypropyl methacrylate
Chloroquine
Chemokines
Hydroxychloroquine
Copolymers
Cells
Chemokine Receptors
Cytotoxicity
Copolymerization
Molecules
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis. / Yu, Fei; Xie, Ying; Wang, Yan; Peng, Zheng Hong; Li, Jing; Oupicky, David.

In: ACS Macro Letters, Vol. 5, No. 3, 15.03.2016, p. 342-345.

Research output: Contribution to journalArticle

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