Chlorella Viruses

Takashi Yamada, Hideki Onimatsu, James L Van Etten

Research output: Chapter in Book/Report/Conference proceedingChapter

92 Citations (Scopus)

Abstract

Chlorella viruses or chloroviruses are large, icosahedral, plaque-forming, double-stranded-DNA-containing viruses that replicate in certain strains of the unicellular green alga Chlorella. DNA sequence analysis of the 330-kbp genome of Paramecium bursaria chlorella virus 1 (PBCV-1), the prototype of this virus family (Phycodnaviridae), predict ∼366 protein-encoding genes and 11 tRNA genes. The predicted gene products of ∼50% of these genes resemble proteins of known function, including many that are completely unexpected for a virus. In addition, the chlorella viruses have several features and encode many gene products that distinguish them from most viruses. These products include: (1) multiple DNA methyltransferases and DNA site-specific endonucleases, (2) the enzymes required to glycosylate their proteins and synthesize polysaccharides such as hyaluronan and chitin, (3) a virus-encoded K+ channel (called Kcv) located in the internal membrane of the virions, (4) a SET domain containing protein (referred to as vSET) that dimethylates Lys27 in histone 3, and (5) PBCV-1 has three types of introns; a self-splicing intron, a spliceosomal processed intron, and a small tRNA intron. Accumulating evidence indicates that the chlorella viruses have a very long evolutionary history. This review mainly deals with research on the virion structure, genome rearrangements, gene expression, cell wall degradation, polysaccharide synthesis, and evolution of PBCV-1 as well as other related viruses.

Original languageEnglish (US)
Title of host publicationAdvances in Virus Research
EditorsKarl Maramorosch, Aaron Shatkin
Pages293-336
Number of pages44
DOIs
StatePublished - Jul 28 2006

Publication series

NameAdvances in Virus Research
Volume65
ISSN (Print)0065-3527

Fingerprint

Chlorella
Viruses
Paramecium
Introns
Transfer RNA
Virion
Polysaccharides
Phycodnaviridae
DNA
Genome
Genes
Chlorophyta
Proteins
Chitin
DNA Viruses
Endonucleases
Methyltransferases
Hyaluronic Acid
DNA Sequence Analysis
Histones

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Yamada, T., Onimatsu, H., & Van Etten, J. L. (2006). Chlorella Viruses. In K. Maramorosch, & A. Shatkin (Eds.), Advances in Virus Research (pp. 293-336). (Advances in Virus Research; Vol. 65). https://doi.org/10.1016/S0065-3527(06)66006-5

Chlorella Viruses. / Yamada, Takashi; Onimatsu, Hideki; Van Etten, James L.

Advances in Virus Research. ed. / Karl Maramorosch; Aaron Shatkin. 2006. p. 293-336 (Advances in Virus Research; Vol. 65).

Research output: Chapter in Book/Report/Conference proceedingChapter

Yamada, T, Onimatsu, H & Van Etten, JL 2006, Chlorella Viruses. in K Maramorosch & A Shatkin (eds), Advances in Virus Research. Advances in Virus Research, vol. 65, pp. 293-336. https://doi.org/10.1016/S0065-3527(06)66006-5
Yamada T, Onimatsu H, Van Etten JL. Chlorella Viruses. In Maramorosch K, Shatkin A, editors, Advances in Virus Research. 2006. p. 293-336. (Advances in Virus Research). https://doi.org/10.1016/S0065-3527(06)66006-5
Yamada, Takashi ; Onimatsu, Hideki ; Van Etten, James L. / Chlorella Viruses. Advances in Virus Research. editor / Karl Maramorosch ; Aaron Shatkin. 2006. pp. 293-336 (Advances in Virus Research).
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