Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV

Masakazu Furuta, John O. Schrader, Holly S. Schrader, Tyler A. Kokjohn, Simon Nyaga, Amanda K. McCullough, R. Stephen Lloyd, Dwight E. Burbank, Dorit Landstein, Les Lane, James L. Van Etten

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52 Scopus citations

Abstract

The bacteriophage T4 denV gene encodes a well-characterized DNA repair enzyme involved in pyrimidine photodimer excision. We have discovered the first homologs of the denV gene in chlorella viruses, which are common in fresh water. This gene functions in vivo and also when cloned in Escherichia coli. Photodamaged virus DNA can also be photoreactivated by the host chlorella. Since the chlorella viruses are continually exposed to solar radiation in their native environments, two separate DNA repair systems, one that functions in the dark and one that functions in the light, significantly enhance their survival.

Original languageEnglish (US)
Pages (from-to)1551-1556
Number of pages6
JournalApplied and environmental microbiology
Volume63
Issue number4
Publication statusPublished - Apr 1 1997

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ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Cite this

Furuta, M., Schrader, J. O., Schrader, H. S., Kokjohn, T. A., Nyaga, S., McCullough, A. K., ... Van Etten, J. L. (1997). Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV. Applied and environmental microbiology, 63(4), 1551-1556.