Chitosan-coated liposomes encapsulating curcumin: Study of lipid-polysaccharide interactions and nanovesicle behavior

M. Hasan, G. Ben Messaoud, F. Michaux, A. Tamayol, C. J.F. Kahn, N. Belhaj, M. Linder, E. Arab-Tehrany

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Despite various spectacular therapeutic properties, curcumin has low bioavailability mainly due to its poor solubility in water. In this paper, we encapsulated curcumin by nanoliposomes prepared from salmon purified phospholipid and coated with chitosan. Various techniques were used in order to study the interactions among phospholipid, chitosan and curcumin. FTIR results showed both electrostatic and hydrophobic interactions as well as hydrogen bonding between chitosan and phospholipid, while hydrophobic forces and hydrogen bonding dominated the interactions between curcumin and phospholipid as well as between curcumin and chitosan. Shear viscosity measurements demonstrated a flow behavior change from Newtonian to shear thinning after liposome coating. The increase/decrease stress ramp showed that the addition of chitosan layer decreased significantly the hysteresis loop area (thixotropic behavior) and therefore increased significantly the liposomal dispersion stability. The viscoelastic properties investigated by small-amplitude oscillatory shear rheology demonstrated improvement of mechanical stability after chitosan addition. Small-angle X-ray scattering experiments revealed that the liposome membrane structure was not affected by the chitosan layer or the encapsulated curcumin.

Original languageEnglish (US)
Pages (from-to)45290-45304
Number of pages15
JournalRSC Advances
Volume6
Issue number51
DOIs
StatePublished - Jan 1 2016

Fingerprint

Curcumin
Liposomes
Chitosan
Polysaccharides
Lipids
Phospholipids
Hydrogen bonds
Membrane structures
Shear viscosity
Shear thinning
Mechanical stability
Viscosity measurement
Hysteresis loops
X ray scattering
Rheology
Electrostatics
Solubility
Coatings
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Hasan, M., Ben Messaoud, G., Michaux, F., Tamayol, A., Kahn, C. J. F., Belhaj, N., ... Arab-Tehrany, E. (2016). Chitosan-coated liposomes encapsulating curcumin: Study of lipid-polysaccharide interactions and nanovesicle behavior. RSC Advances, 6(51), 45290-45304. https://doi.org/10.1039/c6ra05574e

Chitosan-coated liposomes encapsulating curcumin : Study of lipid-polysaccharide interactions and nanovesicle behavior. / Hasan, M.; Ben Messaoud, G.; Michaux, F.; Tamayol, A.; Kahn, C. J.F.; Belhaj, N.; Linder, M.; Arab-Tehrany, E.

In: RSC Advances, Vol. 6, No. 51, 01.01.2016, p. 45290-45304.

Research output: Contribution to journalArticle

Hasan, M, Ben Messaoud, G, Michaux, F, Tamayol, A, Kahn, CJF, Belhaj, N, Linder, M & Arab-Tehrany, E 2016, 'Chitosan-coated liposomes encapsulating curcumin: Study of lipid-polysaccharide interactions and nanovesicle behavior', RSC Advances, vol. 6, no. 51, pp. 45290-45304. https://doi.org/10.1039/c6ra05574e
Hasan, M. ; Ben Messaoud, G. ; Michaux, F. ; Tamayol, A. ; Kahn, C. J.F. ; Belhaj, N. ; Linder, M. ; Arab-Tehrany, E. / Chitosan-coated liposomes encapsulating curcumin : Study of lipid-polysaccharide interactions and nanovesicle behavior. In: RSC Advances. 2016 ; Vol. 6, No. 51. pp. 45290-45304.
@article{3a5b86a3aca742d090ad956fd5ae685e,
title = "Chitosan-coated liposomes encapsulating curcumin: Study of lipid-polysaccharide interactions and nanovesicle behavior",
abstract = "Despite various spectacular therapeutic properties, curcumin has low bioavailability mainly due to its poor solubility in water. In this paper, we encapsulated curcumin by nanoliposomes prepared from salmon purified phospholipid and coated with chitosan. Various techniques were used in order to study the interactions among phospholipid, chitosan and curcumin. FTIR results showed both electrostatic and hydrophobic interactions as well as hydrogen bonding between chitosan and phospholipid, while hydrophobic forces and hydrogen bonding dominated the interactions between curcumin and phospholipid as well as between curcumin and chitosan. Shear viscosity measurements demonstrated a flow behavior change from Newtonian to shear thinning after liposome coating. The increase/decrease stress ramp showed that the addition of chitosan layer decreased significantly the hysteresis loop area (thixotropic behavior) and therefore increased significantly the liposomal dispersion stability. The viscoelastic properties investigated by small-amplitude oscillatory shear rheology demonstrated improvement of mechanical stability after chitosan addition. Small-angle X-ray scattering experiments revealed that the liposome membrane structure was not affected by the chitosan layer or the encapsulated curcumin.",
author = "M. Hasan and {Ben Messaoud}, G. and F. Michaux and A. Tamayol and Kahn, {C. J.F.} and N. Belhaj and M. Linder and E. Arab-Tehrany",
year = "2016",
month = "1",
day = "1",
doi = "10.1039/c6ra05574e",
language = "English (US)",
volume = "6",
pages = "45290--45304",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "51",

}

TY - JOUR

T1 - Chitosan-coated liposomes encapsulating curcumin

T2 - Study of lipid-polysaccharide interactions and nanovesicle behavior

AU - Hasan, M.

AU - Ben Messaoud, G.

AU - Michaux, F.

AU - Tamayol, A.

AU - Kahn, C. J.F.

AU - Belhaj, N.

AU - Linder, M.

AU - Arab-Tehrany, E.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Despite various spectacular therapeutic properties, curcumin has low bioavailability mainly due to its poor solubility in water. In this paper, we encapsulated curcumin by nanoliposomes prepared from salmon purified phospholipid and coated with chitosan. Various techniques were used in order to study the interactions among phospholipid, chitosan and curcumin. FTIR results showed both electrostatic and hydrophobic interactions as well as hydrogen bonding between chitosan and phospholipid, while hydrophobic forces and hydrogen bonding dominated the interactions between curcumin and phospholipid as well as between curcumin and chitosan. Shear viscosity measurements demonstrated a flow behavior change from Newtonian to shear thinning after liposome coating. The increase/decrease stress ramp showed that the addition of chitosan layer decreased significantly the hysteresis loop area (thixotropic behavior) and therefore increased significantly the liposomal dispersion stability. The viscoelastic properties investigated by small-amplitude oscillatory shear rheology demonstrated improvement of mechanical stability after chitosan addition. Small-angle X-ray scattering experiments revealed that the liposome membrane structure was not affected by the chitosan layer or the encapsulated curcumin.

AB - Despite various spectacular therapeutic properties, curcumin has low bioavailability mainly due to its poor solubility in water. In this paper, we encapsulated curcumin by nanoliposomes prepared from salmon purified phospholipid and coated with chitosan. Various techniques were used in order to study the interactions among phospholipid, chitosan and curcumin. FTIR results showed both electrostatic and hydrophobic interactions as well as hydrogen bonding between chitosan and phospholipid, while hydrophobic forces and hydrogen bonding dominated the interactions between curcumin and phospholipid as well as between curcumin and chitosan. Shear viscosity measurements demonstrated a flow behavior change from Newtonian to shear thinning after liposome coating. The increase/decrease stress ramp showed that the addition of chitosan layer decreased significantly the hysteresis loop area (thixotropic behavior) and therefore increased significantly the liposomal dispersion stability. The viscoelastic properties investigated by small-amplitude oscillatory shear rheology demonstrated improvement of mechanical stability after chitosan addition. Small-angle X-ray scattering experiments revealed that the liposome membrane structure was not affected by the chitosan layer or the encapsulated curcumin.

UR - http://www.scopus.com/inward/record.url?scp=84969940666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969940666&partnerID=8YFLogxK

U2 - 10.1039/c6ra05574e

DO - 10.1039/c6ra05574e

M3 - Article

AN - SCOPUS:84969940666

VL - 6

SP - 45290

EP - 45304

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 51

ER -