Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot

Max J. Kurz, Alex I. Wiesman, Nathan M. Coolidge, Tony W. Wilson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.

Original languageEnglish (US)
Pages (from-to)2431-2438
Number of pages8
JournalCerebral cortex (New York, N.Y. : 1991)
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Cerebral Palsy
Foot
Magnetoencephalography
Sensory Gating
Tibial Nerve
Somatosensory Cortex
Neuroimaging
Electric Stimulation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot. / Kurz, Max J.; Wiesman, Alex I.; Coolidge, Nathan M.; Wilson, Tony W.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 28, No. 7, 01.07.2018, p. 2431-2438.

Research output: Contribution to journalArticle

@article{346187d8b34042c792f698d591dfc424,
title = "Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot",
abstract = "We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.",
author = "Kurz, {Max J.} and Wiesman, {Alex I.} and Coolidge, {Nathan M.} and Wilson, {Tony W.}",
year = "2018",
month = "7",
day = "1",
doi = "10.1093/cercor/bhx144",
language = "English (US)",
volume = "28",
pages = "2431--2438",
journal = "Cerebral cortex (New York, N.Y. : 1991)",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot

AU - Kurz, Max J.

AU - Wiesman, Alex I.

AU - Coolidge, Nathan M.

AU - Wilson, Tony W.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.

AB - We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.

UR - http://www.scopus.com/inward/record.url?scp=85067354493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067354493&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhx144

DO - 10.1093/cercor/bhx144

M3 - Article

C2 - 28591842

AN - SCOPUS:85067354493

VL - 28

SP - 2431

EP - 2438

JO - Cerebral cortex (New York, N.Y. : 1991)

JF - Cerebral cortex (New York, N.Y. : 1991)

SN - 1047-3211

IS - 7

ER -