Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement

Fiona Costello, Andrew G. Lee, Adel K. Afifi, Praful Kelkar, Randy H. Kardon, Matthew White

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A 17-year-old male presented with chronic diplopia and generalized motor weakness. He was previously diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy and acute disseminated encephalomyelitis in childhood. Cranial magnetic resonance imaging (MRI) revealed a rarely reported finding of thickening and enhancement of multiple cranial nerves. Nerve conduction studies and electromyography showed peripheral nerve demyelination with axonal involvement. There was improvement in the clinical examination, MRI, and electrophysiologic studies after combined corticosteroid and plasma exchange therapy. We review the clinical presentation, course, and response to therapy among children with chronic inflammatory demyelinating polyradiculoneuropathy, with specific emphasis on the frequency and pattern of cranial nerve involvement.

Original languageEnglish (US)
Pages (from-to)819-823
Number of pages5
JournalJournal of Child Neurology
Volume17
Issue number11
DOIs
StatePublished - Nov 1 2002

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Cranial Nerves
Magnetic Resonance Imaging
Acute Disseminated Encephalomyelitis
Plasma Exchange
Diplopia
Neural Conduction
Electromyography
Demyelinating Diseases
Peripheral Nerves
Adrenal Cortex Hormones
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement. / Costello, Fiona; Lee, Andrew G.; Afifi, Adel K.; Kelkar, Praful; Kardon, Randy H.; White, Matthew.

In: Journal of Child Neurology, Vol. 17, No. 11, 01.11.2002, p. 819-823.

Research output: Contribution to journalArticle

Costello, Fiona ; Lee, Andrew G. ; Afifi, Adel K. ; Kelkar, Praful ; Kardon, Randy H. ; White, Matthew. / Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement. In: Journal of Child Neurology. 2002 ; Vol. 17, No. 11. pp. 819-823.
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