Childhood obesity increases left-ventricular mass irrespective of blood pressure status

A. M. Kharod, S. R. Ramlogan, S. Kumar, T. Raghuveer, W. Drake, H. Dai, G. Raghuveer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Adults with a left-ventricular mass index (LVMI) in grams normalized to height in meters2.7 (LVMI g/m2.7) >51 g/m2.7 are more prone to cardiovascular and cerebrovascular events. We delineated the odds for cardiac structural sequelae amongst apparently normal white and African-American (AA) children with varying body mass indices (BMI) and office blood pressures. A total of 2,071 children with normal echocardiograms were categorized into risk groups based on BMI and systolic blood pressures (SBPs). Predictors of cardiac sequelae examined were age, sex, race, and z-scores (z) for BMI, SBP, and diastolic blood pressure. Cardiac sequelae measures included (LVMI g/m2.7) >51 g/m2.7, (LVMI) (g/m2.7) z, left atrial size (LAht) (mm) z, and relative wall thickness z. Mean age was 14 ± 2 years with 56 % being male and 13 % being AA. Children were divided into "controls" (n = 1,059) and risk groups based on BMI and SBP. Odds ratio for LVMI (g/m2.7) > 51.0 g/m2.7, varied from 5.3 up to 8.5 in children with increased BMI. Both increased BMI and SBP z were associated with increased LVMI (g/m2.7) z; however, BMI z had a stronger association. Increased BMI z and AA race were associated with greater LAht (mm) z. AA controls had a nonsignificantly increased LVMI z and a significantly increased LAht (mm) and RWT z. Being overweight or obese is associated with cardiac sequelae in children to the extent known to be associated with adverse outcomes in adults. Healthy AA children have unique cardiac structural differences.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalPediatric Cardiology
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2014

Fingerprint

Pediatric Obesity
Blood Pressure
Body Mass Index
African Americans
Odds Ratio

Keywords

  • Body mass index
  • Cardiac structure and ethnicity
  • Children
  • Left atrial size
  • Left-ventricular mass index

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Kharod, A. M., Ramlogan, S. R., Kumar, S., Raghuveer, T., Drake, W., Dai, H., & Raghuveer, G. (2014). Childhood obesity increases left-ventricular mass irrespective of blood pressure status. Pediatric Cardiology, 35(2), 353-360. https://doi.org/10.1007/s00246-013-0782-5

Childhood obesity increases left-ventricular mass irrespective of blood pressure status. / Kharod, A. M.; Ramlogan, S. R.; Kumar, S.; Raghuveer, T.; Drake, W.; Dai, H.; Raghuveer, G.

In: Pediatric Cardiology, Vol. 35, No. 2, 01.02.2014, p. 353-360.

Research output: Contribution to journalArticle

Kharod, AM, Ramlogan, SR, Kumar, S, Raghuveer, T, Drake, W, Dai, H & Raghuveer, G 2014, 'Childhood obesity increases left-ventricular mass irrespective of blood pressure status', Pediatric Cardiology, vol. 35, no. 2, pp. 353-360. https://doi.org/10.1007/s00246-013-0782-5
Kharod, A. M. ; Ramlogan, S. R. ; Kumar, S. ; Raghuveer, T. ; Drake, W. ; Dai, H. ; Raghuveer, G. / Childhood obesity increases left-ventricular mass irrespective of blood pressure status. In: Pediatric Cardiology. 2014 ; Vol. 35, No. 2. pp. 353-360.
@article{43b26ed7aaba40c598038d05ab29ca7d,
title = "Childhood obesity increases left-ventricular mass irrespective of blood pressure status",
abstract = "Adults with a left-ventricular mass index (LVMI) in grams normalized to height in meters2.7 (LVMI g/m2.7) >51 g/m2.7 are more prone to cardiovascular and cerebrovascular events. We delineated the odds for cardiac structural sequelae amongst apparently normal white and African-American (AA) children with varying body mass indices (BMI) and office blood pressures. A total of 2,071 children with normal echocardiograms were categorized into risk groups based on BMI and systolic blood pressures (SBPs). Predictors of cardiac sequelae examined were age, sex, race, and z-scores (z) for BMI, SBP, and diastolic blood pressure. Cardiac sequelae measures included (LVMI g/m2.7) >51 g/m2.7, (LVMI) (g/m2.7) z, left atrial size (LAht) (mm) z, and relative wall thickness z. Mean age was 14 ± 2 years with 56 {\%} being male and 13 {\%} being AA. Children were divided into {"}controls{"} (n = 1,059) and risk groups based on BMI and SBP. Odds ratio for LVMI (g/m2.7) > 51.0 g/m2.7, varied from 5.3 up to 8.5 in children with increased BMI. Both increased BMI and SBP z were associated with increased LVMI (g/m2.7) z; however, BMI z had a stronger association. Increased BMI z and AA race were associated with greater LAht (mm) z. AA controls had a nonsignificantly increased LVMI z and a significantly increased LAht (mm) and RWT z. Being overweight or obese is associated with cardiac sequelae in children to the extent known to be associated with adverse outcomes in adults. Healthy AA children have unique cardiac structural differences.",
keywords = "Body mass index, Cardiac structure and ethnicity, Children, Left atrial size, Left-ventricular mass index",
author = "Kharod, {A. M.} and Ramlogan, {S. R.} and S. Kumar and T. Raghuveer and W. Drake and H. Dai and G. Raghuveer",
year = "2014",
month = "2",
day = "1",
doi = "10.1007/s00246-013-0782-5",
language = "English (US)",
volume = "35",
pages = "353--360",
journal = "Pediatric Cardiology",
issn = "0172-0643",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Childhood obesity increases left-ventricular mass irrespective of blood pressure status

AU - Kharod, A. M.

AU - Ramlogan, S. R.

AU - Kumar, S.

AU - Raghuveer, T.

AU - Drake, W.

AU - Dai, H.

AU - Raghuveer, G.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Adults with a left-ventricular mass index (LVMI) in grams normalized to height in meters2.7 (LVMI g/m2.7) >51 g/m2.7 are more prone to cardiovascular and cerebrovascular events. We delineated the odds for cardiac structural sequelae amongst apparently normal white and African-American (AA) children with varying body mass indices (BMI) and office blood pressures. A total of 2,071 children with normal echocardiograms were categorized into risk groups based on BMI and systolic blood pressures (SBPs). Predictors of cardiac sequelae examined were age, sex, race, and z-scores (z) for BMI, SBP, and diastolic blood pressure. Cardiac sequelae measures included (LVMI g/m2.7) >51 g/m2.7, (LVMI) (g/m2.7) z, left atrial size (LAht) (mm) z, and relative wall thickness z. Mean age was 14 ± 2 years with 56 % being male and 13 % being AA. Children were divided into "controls" (n = 1,059) and risk groups based on BMI and SBP. Odds ratio for LVMI (g/m2.7) > 51.0 g/m2.7, varied from 5.3 up to 8.5 in children with increased BMI. Both increased BMI and SBP z were associated with increased LVMI (g/m2.7) z; however, BMI z had a stronger association. Increased BMI z and AA race were associated with greater LAht (mm) z. AA controls had a nonsignificantly increased LVMI z and a significantly increased LAht (mm) and RWT z. Being overweight or obese is associated with cardiac sequelae in children to the extent known to be associated with adverse outcomes in adults. Healthy AA children have unique cardiac structural differences.

AB - Adults with a left-ventricular mass index (LVMI) in grams normalized to height in meters2.7 (LVMI g/m2.7) >51 g/m2.7 are more prone to cardiovascular and cerebrovascular events. We delineated the odds for cardiac structural sequelae amongst apparently normal white and African-American (AA) children with varying body mass indices (BMI) and office blood pressures. A total of 2,071 children with normal echocardiograms were categorized into risk groups based on BMI and systolic blood pressures (SBPs). Predictors of cardiac sequelae examined were age, sex, race, and z-scores (z) for BMI, SBP, and diastolic blood pressure. Cardiac sequelae measures included (LVMI g/m2.7) >51 g/m2.7, (LVMI) (g/m2.7) z, left atrial size (LAht) (mm) z, and relative wall thickness z. Mean age was 14 ± 2 years with 56 % being male and 13 % being AA. Children were divided into "controls" (n = 1,059) and risk groups based on BMI and SBP. Odds ratio for LVMI (g/m2.7) > 51.0 g/m2.7, varied from 5.3 up to 8.5 in children with increased BMI. Both increased BMI and SBP z were associated with increased LVMI (g/m2.7) z; however, BMI z had a stronger association. Increased BMI z and AA race were associated with greater LAht (mm) z. AA controls had a nonsignificantly increased LVMI z and a significantly increased LAht (mm) and RWT z. Being overweight or obese is associated with cardiac sequelae in children to the extent known to be associated with adverse outcomes in adults. Healthy AA children have unique cardiac structural differences.

KW - Body mass index

KW - Cardiac structure and ethnicity

KW - Children

KW - Left atrial size

KW - Left-ventricular mass index

UR - http://www.scopus.com/inward/record.url?scp=84893654708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893654708&partnerID=8YFLogxK

U2 - 10.1007/s00246-013-0782-5

DO - 10.1007/s00246-013-0782-5

M3 - Article

C2 - 23989657

AN - SCOPUS:84893654708

VL - 35

SP - 353

EP - 360

JO - Pediatric Cardiology

JF - Pediatric Cardiology

SN - 0172-0643

IS - 2

ER -