Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses

J. H. Kersey, T. W. LeBien, R. Hurwitz, M. E. Nesbit, K. J. Gajl-Peczalska, D. Hammond, D. R. Miller, P. F. Coccia, S. Leikin

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Abstract

Results are reported on 724 children and adolescents with acute leukemia-lymphoma. One hundred patients had immunologic marker analysis that defined the major phenotypic groups, i.e., T-cell, B-cell (Burkitt), myeloid, and the most frequent form, non-T, non-B 'common' or 'undifferentiated' acute leukemia. Pre-T, pre-B, and 'null' leukemias are included in the latter group. Response to therapy and survival was best in non-T, non-B acute lymphocytic leukemia, intermediate in T-cell disease, and worst in B-cell (Burkitt) disease. Additional factors resulting in decreased survival include elevated peripheral leukocyte count, presence of enlarged nodes, less depression of hemoglobin and platelets, and age greater than 7 years (all associated with 'lymphomatous' disease). Other factors resulting in decreased survival include age under 3 years and depression of serum immunoglobulins. Definition of the heterogeneity of childhood leukemia-lymphoma dictates differing forms of therapy for the various types of these diseases.

Original languageEnglish (US)
Pages (from-to)746-752
Number of pages7
JournalAmerican journal of clinical pathology
Volume72
Issue number4 Suppl.
StatePublished - Dec 1 1979

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Lymphoma
Leukemia
Phenotype
Survival
B-Lymphocytes
T-Lymphocytes
Leukocyte Count
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulins
Hemoglobins
Blood Platelets
Biomarkers
Therapeutics
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kersey, J. H., LeBien, T. W., Hurwitz, R., Nesbit, M. E., Gajl-Peczalska, K. J., Hammond, D., ... Leikin, S. (1979). Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses. American journal of clinical pathology, 72(4 Suppl.), 746-752.

Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses. / Kersey, J. H.; LeBien, T. W.; Hurwitz, R.; Nesbit, M. E.; Gajl-Peczalska, K. J.; Hammond, D.; Miller, D. R.; Coccia, P. F.; Leikin, S.

In: American journal of clinical pathology, Vol. 72, No. 4 Suppl., 01.12.1979, p. 746-752.

Research output: Contribution to journalArticle

Kersey, JH, LeBien, TW, Hurwitz, R, Nesbit, ME, Gajl-Peczalska, KJ, Hammond, D, Miller, DR, Coccia, PF & Leikin, S 1979, 'Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses', American journal of clinical pathology, vol. 72, no. 4 Suppl., pp. 746-752.
Kersey JH, LeBien TW, Hurwitz R, Nesbit ME, Gajl-Peczalska KJ, Hammond D et al. Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses. American journal of clinical pathology. 1979 Dec 1;72(4 Suppl.):746-752.
Kersey, J. H. ; LeBien, T. W. ; Hurwitz, R. ; Nesbit, M. E. ; Gajl-Peczalska, K. J. ; Hammond, D. ; Miller, D. R. ; Coccia, P. F. ; Leikin, S. / Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses. In: American journal of clinical pathology. 1979 ; Vol. 72, No. 4 Suppl. pp. 746-752.
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