Chicken soup inhibits neutrophil chemotaxis in vitro

B. O. Rennard, R. F. Ertl, G. L. Gossman, R. A. Robbins, S. I. Rennard

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Chicken soup has long been regarded as a remedy for symptomatic upper respiratory tract infections. As it is likely that the clinical similarity of the diverse infectious processes that can result in 'colds' is due to a shared inflammatory response, an effect of chicken soup in mitigating inflammation could account for its attested benefits. To evaluate this, a traditional chicken soup was tested for its ability to inhibit neutrophil migration using the standard Boyden blindwell chemotaxis chamber assay with zymosan-activated serum and fMet-Leu-Phe as chemoattractants. Chicken soup significantly inhibited neutrophil migration and did so in a concentration-dependent manner. The activity was present in a nonparticulate component of the chicken soup. All of the vegetables present in the soup and the chicken individually had anhibitory activity, although only the chicken lacked cytotoxic activity. Interestingly, the complete soup also lacked cytotoxic activity. Commercial soups varied greatly in their inhibitory activity. The present study, therefore, suggests that chicken soup may contain a number of substances with beneficial medicinal activity. A mild anti-inflammatory effect could be one mechanism by which the soup could result in the mitigation of symptomatic upper respiratory tract infections.

Original languageEnglish (US)
Pages (from-to)1150-1157
Number of pages8
JournalChest
Volume118
Issue number4
DOIs
StatePublished - Jan 1 2000

Fingerprint

Chemotaxis
Chickens
Neutrophils
Respiratory Tract Infections
N-Formylmethionine Leucyl-Phenylalanine
Aptitude
Zymosan
In Vitro Techniques
Chemotactic Factors
Vegetables
Anti-Inflammatory Agents
Inflammation
Serum

Keywords

  • Chicken soup
  • Neutrophil chemotaxis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Rennard, B. O., Ertl, R. F., Gossman, G. L., Robbins, R. A., & Rennard, S. I. (2000). Chicken soup inhibits neutrophil chemotaxis in vitro. Chest, 118(4), 1150-1157. https://doi.org/10.1378/chest.118.4.1150

Chicken soup inhibits neutrophil chemotaxis in vitro. / Rennard, B. O.; Ertl, R. F.; Gossman, G. L.; Robbins, R. A.; Rennard, S. I.

In: Chest, Vol. 118, No. 4, 01.01.2000, p. 1150-1157.

Research output: Contribution to journalArticle

Rennard, BO, Ertl, RF, Gossman, GL, Robbins, RA & Rennard, SI 2000, 'Chicken soup inhibits neutrophil chemotaxis in vitro', Chest, vol. 118, no. 4, pp. 1150-1157. https://doi.org/10.1378/chest.118.4.1150
Rennard BO, Ertl RF, Gossman GL, Robbins RA, Rennard SI. Chicken soup inhibits neutrophil chemotaxis in vitro. Chest. 2000 Jan 1;118(4):1150-1157. https://doi.org/10.1378/chest.118.4.1150
Rennard, B. O. ; Ertl, R. F. ; Gossman, G. L. ; Robbins, R. A. ; Rennard, S. I. / Chicken soup inhibits neutrophil chemotaxis in vitro. In: Chest. 2000 ; Vol. 118, No. 4. pp. 1150-1157.
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