Chiasma-based models of multilocus recombination: Increased power for exclusion mapping and gene ordering

David E. Goldgar, Pamela R. Fain, William J. Kimberling

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalGenomics
Volume5
Issue number2
DOIs
StatePublished - Aug 1989

Fingerprint

Chromosome Mapping
Genetic Recombination
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Chiasma-based models of multilocus recombination : Increased power for exclusion mapping and gene ordering. / Goldgar, David E.; Fain, Pamela R.; Kimberling, William J.

In: Genomics, Vol. 5, No. 2, 08.1989, p. 283-290.

Research output: Contribution to journalArticle

Goldgar, David E. ; Fain, Pamela R. ; Kimberling, William J. / Chiasma-based models of multilocus recombination : Increased power for exclusion mapping and gene ordering. In: Genomics. 1989 ; Vol. 5, No. 2. pp. 283-290.
@article{e61a93f4e68c434ab634daa98c47078f,
title = "Chiasma-based models of multilocus recombination: Increased power for exclusion mapping and gene ordering",
abstract = "Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.",
author = "Goldgar, {David E.} and Fain, {Pamela R.} and Kimberling, {William J.}",
year = "1989",
month = "8",
doi = "10.1016/0888-7543(89)90059-1",
language = "English (US)",
volume = "5",
pages = "283--290",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Chiasma-based models of multilocus recombination

T2 - Increased power for exclusion mapping and gene ordering

AU - Goldgar, David E.

AU - Fain, Pamela R.

AU - Kimberling, William J.

PY - 1989/8

Y1 - 1989/8

N2 - Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.

AB - Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.

UR - http://www.scopus.com/inward/record.url?scp=0024709640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024709640&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(89)90059-1

DO - 10.1016/0888-7543(89)90059-1

M3 - Article

C2 - 2793183

AN - SCOPUS:0024709640

VL - 5

SP - 283

EP - 290

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -