Chest CT Measures of Muscle and Adipose Tissue in COPD

Gender-based Differences in Content and in Relationships with Blood Biomarkers

Alejandro A. Diaz, Linfu Zhou, Tom P. Young, Merry Lynn McDonald, Rola Harmouche, James C. Ross, Raul San Jose Estepar, Emiel F.M. Wouters, Harvey O. Coxson, William MacNee, Stephen Israel Rennard, François Maltais, Gregory L. Kinney, John E. Hokanson, George R. Washko

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Rationale and Objectives: Computed tomography (CT) of the chest can be used to assess pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) area. Adipose tissue content is associated with inflammatory mediators in chronic obstructive pulmonary disease (COPD) subjects. Based on gender differences in body composition, we aimed to assess the hypothesis that in subjects with COPD, the relationships between PMA, SAT, and blood biomarkers of inflammation differ by gender. Materials and Methods: We compared chest CT measures of PMA and SAT on a single slice at aortic arch and supraesternal notch levels from 73 subjects (28 women) with COPD between genders. The relationships of PMA and SAT area to biomarkers were assessed using within-gender regression models. Results: Women had a lesser PMA and a greater SAT area than men (difference range for PMA, 13.3-22.8cm2; for SAT, 11.8-12.4cm2; P<.05 for all comparisons) at both anatomic levels. These differences in PMA and SAT remained significant after adjustment for age and body mass index. Within-gender regression models adjusted for age showed that SAT was directly associated with C-reactive protein (for aortic arch level, P=04) and fibrinogen (for both anatomic locations, P=003) only in women, whereas PMA was not associated with any biomarkers in either gender. Conclusions: It appears that in subjects with COPD, there are gender-based differences in the relationships between subcutaneous adipose tissue and inflammatory biomarkers.

Original languageEnglish (US)
Pages (from-to)1255-1261
Number of pages7
JournalAcademic Radiology
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Pectoralis Muscles
Subcutaneous Fat
Chronic Obstructive Pulmonary Disease
Adipose Tissue
Thorax
Biomarkers
Tomography
Muscles
Thoracic Aorta
Body Composition
C-Reactive Protein
Fibrinogen
Body Mass Index
Inflammation

Keywords

  • Adipose subcutaneous tissue
  • Biomarkers
  • COPD
  • CRP
  • CT
  • Fibrinogen
  • IL-6
  • Pectoralis muscle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diaz, A. A., Zhou, L., Young, T. P., McDonald, M. L., Harmouche, R., Ross, J. C., ... Washko, G. R. (2014). Chest CT Measures of Muscle and Adipose Tissue in COPD: Gender-based Differences in Content and in Relationships with Blood Biomarkers. Academic Radiology, 21(10), 1255-1261. https://doi.org/10.1016/j.acra.2014.05.013

Chest CT Measures of Muscle and Adipose Tissue in COPD : Gender-based Differences in Content and in Relationships with Blood Biomarkers. / Diaz, Alejandro A.; Zhou, Linfu; Young, Tom P.; McDonald, Merry Lynn; Harmouche, Rola; Ross, James C.; San Jose Estepar, Raul; Wouters, Emiel F.M.; Coxson, Harvey O.; MacNee, William; Rennard, Stephen Israel; Maltais, François; Kinney, Gregory L.; Hokanson, John E.; Washko, George R.

In: Academic Radiology, Vol. 21, No. 10, 01.10.2014, p. 1255-1261.

Research output: Contribution to journalArticle

Diaz, AA, Zhou, L, Young, TP, McDonald, ML, Harmouche, R, Ross, JC, San Jose Estepar, R, Wouters, EFM, Coxson, HO, MacNee, W, Rennard, SI, Maltais, F, Kinney, GL, Hokanson, JE & Washko, GR 2014, 'Chest CT Measures of Muscle and Adipose Tissue in COPD: Gender-based Differences in Content and in Relationships with Blood Biomarkers', Academic Radiology, vol. 21, no. 10, pp. 1255-1261. https://doi.org/10.1016/j.acra.2014.05.013
Diaz, Alejandro A. ; Zhou, Linfu ; Young, Tom P. ; McDonald, Merry Lynn ; Harmouche, Rola ; Ross, James C. ; San Jose Estepar, Raul ; Wouters, Emiel F.M. ; Coxson, Harvey O. ; MacNee, William ; Rennard, Stephen Israel ; Maltais, François ; Kinney, Gregory L. ; Hokanson, John E. ; Washko, George R. / Chest CT Measures of Muscle and Adipose Tissue in COPD : Gender-based Differences in Content and in Relationships with Blood Biomarkers. In: Academic Radiology. 2014 ; Vol. 21, No. 10. pp. 1255-1261.
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T2 - Gender-based Differences in Content and in Relationships with Blood Biomarkers

AU - Diaz, Alejandro A.

AU - Zhou, Linfu

AU - Young, Tom P.

AU - McDonald, Merry Lynn

AU - Harmouche, Rola

AU - Ross, James C.

AU - San Jose Estepar, Raul

AU - Wouters, Emiel F.M.

AU - Coxson, Harvey O.

AU - MacNee, William

AU - Rennard, Stephen Israel

AU - Maltais, François

AU - Kinney, Gregory L.

AU - Hokanson, John E.

AU - Washko, George R.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Rationale and Objectives: Computed tomography (CT) of the chest can be used to assess pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) area. Adipose tissue content is associated with inflammatory mediators in chronic obstructive pulmonary disease (COPD) subjects. Based on gender differences in body composition, we aimed to assess the hypothesis that in subjects with COPD, the relationships between PMA, SAT, and blood biomarkers of inflammation differ by gender. Materials and Methods: We compared chest CT measures of PMA and SAT on a single slice at aortic arch and supraesternal notch levels from 73 subjects (28 women) with COPD between genders. The relationships of PMA and SAT area to biomarkers were assessed using within-gender regression models. Results: Women had a lesser PMA and a greater SAT area than men (difference range for PMA, 13.3-22.8cm2; for SAT, 11.8-12.4cm2; P<.05 for all comparisons) at both anatomic levels. These differences in PMA and SAT remained significant after adjustment for age and body mass index. Within-gender regression models adjusted for age showed that SAT was directly associated with C-reactive protein (for aortic arch level, P=04) and fibrinogen (for both anatomic locations, P=003) only in women, whereas PMA was not associated with any biomarkers in either gender. Conclusions: It appears that in subjects with COPD, there are gender-based differences in the relationships between subcutaneous adipose tissue and inflammatory biomarkers.

AB - Rationale and Objectives: Computed tomography (CT) of the chest can be used to assess pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) area. Adipose tissue content is associated with inflammatory mediators in chronic obstructive pulmonary disease (COPD) subjects. Based on gender differences in body composition, we aimed to assess the hypothesis that in subjects with COPD, the relationships between PMA, SAT, and blood biomarkers of inflammation differ by gender. Materials and Methods: We compared chest CT measures of PMA and SAT on a single slice at aortic arch and supraesternal notch levels from 73 subjects (28 women) with COPD between genders. The relationships of PMA and SAT area to biomarkers were assessed using within-gender regression models. Results: Women had a lesser PMA and a greater SAT area than men (difference range for PMA, 13.3-22.8cm2; for SAT, 11.8-12.4cm2; P<.05 for all comparisons) at both anatomic levels. These differences in PMA and SAT remained significant after adjustment for age and body mass index. Within-gender regression models adjusted for age showed that SAT was directly associated with C-reactive protein (for aortic arch level, P=04) and fibrinogen (for both anatomic locations, P=003) only in women, whereas PMA was not associated with any biomarkers in either gender. Conclusions: It appears that in subjects with COPD, there are gender-based differences in the relationships between subcutaneous adipose tissue and inflammatory biomarkers.

KW - Adipose subcutaneous tissue

KW - Biomarkers

KW - COPD

KW - CRP

KW - CT

KW - Fibrinogen

KW - IL-6

KW - Pectoralis muscle

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