Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J. Padanilam, H. S. Stadler, K. A. Mills, L. B. Mcleod, M. Solursh, B. Lee, F. Ramirez, K. H. Buetow, J. C. Murray

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalHuman Molecular Genetics
Volume1
Issue number6
DOIs
StatePublished - Sep 1 1992

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Complementary DNA
Clone Cells
Dinucleotide Repeats
Chromosome Mapping
Linkage Disequilibrium
Restriction Fragment Length Polymorphisms
Genes
Libraries
Drosophila
Alleles

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Padanilam, B. J., Stadler, H. S., Mills, K. A., Mcleod, L. B., Solursh, M., Lee, B., ... Murray, J. C. (1992). Characterization of the human HOX 7 cDNA and identification of polymorphic markers. Human Molecular Genetics, 1(6), 407-410. https://doi.org/10.1093/hmg/1.6.407

Characterization of the human HOX 7 cDNA and identification of polymorphic markers. / Padanilam, B. J.; Stadler, H. S.; Mills, K. A.; Mcleod, L. B.; Solursh, M.; Lee, B.; Ramirez, F.; Buetow, K. H.; Murray, J. C.

In: Human Molecular Genetics, Vol. 1, No. 6, 01.09.1992, p. 407-410.

Research output: Contribution to journalArticle

Padanilam, BJ, Stadler, HS, Mills, KA, Mcleod, LB, Solursh, M, Lee, B, Ramirez, F, Buetow, KH & Murray, JC 1992, 'Characterization of the human HOX 7 cDNA and identification of polymorphic markers', Human Molecular Genetics, vol. 1, no. 6, pp. 407-410. https://doi.org/10.1093/hmg/1.6.407
Padanilam, B. J. ; Stadler, H. S. ; Mills, K. A. ; Mcleod, L. B. ; Solursh, M. ; Lee, B. ; Ramirez, F. ; Buetow, K. H. ; Murray, J. C. / Characterization of the human HOX 7 cDNA and identification of polymorphic markers. In: Human Molecular Genetics. 1992 ; Vol. 1, No. 6. pp. 407-410.
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