Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA

Peter R. Kraus, Amy F. Hofmann, Steven D. Harris

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The 14-3-3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin-dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14-3-3 homologue (artA) that may function in an analogous manner to prevent septum formation. However, instead of blocking septation, over-expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalFEMS Microbiology Letters
Volume210
Issue number1
DOIs
StatePublished - Apr 23 2002

Fingerprint

Aspergillus nidulans
14-3-3 Proteins
Proteins
Cyclin-Dependent Kinases
Morphogenesis
DNA Damage
Fungi

Keywords

  • 14-3-3
  • Aspergillus
  • Cell cycle checkpoint
  • Fungal
  • Polarity
  • Septation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA. / Kraus, Peter R.; Hofmann, Amy F.; Harris, Steven D.

In: FEMS Microbiology Letters, Vol. 210, No. 1, 23.04.2002, p. 61-66.

Research output: Contribution to journalArticle

Kraus, Peter R. ; Hofmann, Amy F. ; Harris, Steven D. / Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA. In: FEMS Microbiology Letters. 2002 ; Vol. 210, No. 1. pp. 61-66.
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