Characterization of responses of primary somatosensory cerebral cortex neurons to noxious visceral stimulation in the rat

Kenneth A. Follett, Bret Dirks

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In pentobarbital-anesthetized rats, responses of single neurons in primary somatosensory cortex (SI) to graded noxious visceral (colorectal distention, CRD) and cutaneous stimulation were recorded. One-hundred fifteen SI neurons were identified on the basis of spontaneous activity, 66 of which responded to CRD. CRD resulted in facilitation of neuronal activity in 33% and inhibition of activity in 52% of these cells. Fifteen percent had mixed facilitated/inhibited responses to varying CRD pressures. Cutaneous receptive fields were identified in 71% of CRD-responsive neurons, with low-threshold or wide dynamic range responses in most cases. Nearly all cutaneous receptive fields were small contralateral sites. Responses to CRD were independent of neuronal depth within the cortex. These data support a role of primary somatosensory cerebral cortical neurons in visceral nociception.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalBrain Research
Volume656
Issue number1
DOIs
StatePublished - Sep 5 1994

Fingerprint

Somatosensory Cortex
Cerebral Cortex
Neurons
Skin
Nociception
Pentobarbital
Pressure

Keywords

  • Colorectal distention
  • Nociception
  • Pain
  • Viscera

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Characterization of responses of primary somatosensory cerebral cortex neurons to noxious visceral stimulation in the rat. / Follett, Kenneth A.; Dirks, Bret.

In: Brain Research, Vol. 656, No. 1, 05.09.1994, p. 27-32.

Research output: Contribution to journalArticle

@article{8aab187086bb4ce69a56ad5d866c5b35,
title = "Characterization of responses of primary somatosensory cerebral cortex neurons to noxious visceral stimulation in the rat",
abstract = "In pentobarbital-anesthetized rats, responses of single neurons in primary somatosensory cortex (SI) to graded noxious visceral (colorectal distention, CRD) and cutaneous stimulation were recorded. One-hundred fifteen SI neurons were identified on the basis of spontaneous activity, 66 of which responded to CRD. CRD resulted in facilitation of neuronal activity in 33{\%} and inhibition of activity in 52{\%} of these cells. Fifteen percent had mixed facilitated/inhibited responses to varying CRD pressures. Cutaneous receptive fields were identified in 71{\%} of CRD-responsive neurons, with low-threshold or wide dynamic range responses in most cases. Nearly all cutaneous receptive fields were small contralateral sites. Responses to CRD were independent of neuronal depth within the cortex. These data support a role of primary somatosensory cerebral cortical neurons in visceral nociception.",
keywords = "Colorectal distention, Nociception, Pain, Viscera",
author = "Follett, {Kenneth A.} and Bret Dirks",
year = "1994",
month = "9",
day = "5",
doi = "10.1016/0006-8993(94)91362-5",
language = "English (US)",
volume = "656",
pages = "27--32",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Characterization of responses of primary somatosensory cerebral cortex neurons to noxious visceral stimulation in the rat

AU - Follett, Kenneth A.

AU - Dirks, Bret

PY - 1994/9/5

Y1 - 1994/9/5

N2 - In pentobarbital-anesthetized rats, responses of single neurons in primary somatosensory cortex (SI) to graded noxious visceral (colorectal distention, CRD) and cutaneous stimulation were recorded. One-hundred fifteen SI neurons were identified on the basis of spontaneous activity, 66 of which responded to CRD. CRD resulted in facilitation of neuronal activity in 33% and inhibition of activity in 52% of these cells. Fifteen percent had mixed facilitated/inhibited responses to varying CRD pressures. Cutaneous receptive fields were identified in 71% of CRD-responsive neurons, with low-threshold or wide dynamic range responses in most cases. Nearly all cutaneous receptive fields were small contralateral sites. Responses to CRD were independent of neuronal depth within the cortex. These data support a role of primary somatosensory cerebral cortical neurons in visceral nociception.

AB - In pentobarbital-anesthetized rats, responses of single neurons in primary somatosensory cortex (SI) to graded noxious visceral (colorectal distention, CRD) and cutaneous stimulation were recorded. One-hundred fifteen SI neurons were identified on the basis of spontaneous activity, 66 of which responded to CRD. CRD resulted in facilitation of neuronal activity in 33% and inhibition of activity in 52% of these cells. Fifteen percent had mixed facilitated/inhibited responses to varying CRD pressures. Cutaneous receptive fields were identified in 71% of CRD-responsive neurons, with low-threshold or wide dynamic range responses in most cases. Nearly all cutaneous receptive fields were small contralateral sites. Responses to CRD were independent of neuronal depth within the cortex. These data support a role of primary somatosensory cerebral cortical neurons in visceral nociception.

KW - Colorectal distention

KW - Nociception

KW - Pain

KW - Viscera

UR - http://www.scopus.com/inward/record.url?scp=0028093240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028093240&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)91362-5

DO - 10.1016/0006-8993(94)91362-5

M3 - Article

C2 - 7804842

AN - SCOPUS:0028093240

VL - 656

SP - 27

EP - 32

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -