Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998

A. Carattoli, F. Tosini, W. P. Giles, Mark Edmund Rupp, Steven Heye Hinrichs, F. J. Angulo, T. J. Barrett, Paul D Fey

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

Original languageEnglish (US)
Pages (from-to)1269-1272
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number5
DOIs
StatePublished - May 2 2002

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Ceftriaxone
Cephalosporins
Salmonella
Plasmids
DNA Sequence Analysis
Genes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998. / Carattoli, A.; Tosini, F.; Giles, W. P.; Rupp, Mark Edmund; Hinrichs, Steven Heye; Angulo, F. J.; Barrett, T. J.; Fey, Paul D.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 5, 02.05.2002, p. 1269-1272.

Research output: Contribution to journalArticle

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