Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes

Meihui Ma, Jonathan D. Geiger, Avindra Nath

Research output: Contribution to journalComment/debate

65 Citations (Scopus)

Abstract

125I-labeled recombinant gp120 bound to primary cultures of human fetal astrocytes with a single class of 260-kDa binding sites, with a K(d) of 26 nM and maximal number of binding sites of 29.9 fmol/4 x 104 cells. Neither CD4 nor galactocerebroside was detectable on astrocytes, and 125I-labeled recombinant gp120 binding to astrocytes was not blocked by antibodies against galactocerebroside or the gp120 binding domain of CD4.

Original languageEnglish (US)
Pages (from-to)6824-6828
Number of pages5
JournalJournal of virology
Volume68
Issue number10
StatePublished - Oct 1 1994

Fingerprint

Human Immunodeficiency Virus env Gene Products
astrocytes
Human immunodeficiency virus 1
Astrocytes
HIV-1
binding sites
Binding Sites
proteins
antibodies
Antibodies
cells
galactocerebroside

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes. / Ma, Meihui; Geiger, Jonathan D.; Nath, Avindra.

In: Journal of virology, Vol. 68, No. 10, 01.10.1994, p. 6824-6828.

Research output: Contribution to journalComment/debate

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