Characterisation of COPD heterogeneity in the ECLIPSE cohort

Alvar Agusti, Peter M.A. Calverley, Bartolome Celli, Harvey O. Coxson, Lisa D. Edwards, David A. Lomas, William MacNee, Bruce E. Miller, Stephen Israel Rennard, Edwin K. Silverman, Ruth Tal-Singer, Emiel Wouters, Julie C. Yates, Jørgen Vestbo

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Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE).Methods: We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography.Results: COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified.Conclusions: The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.

Original languageEnglish (US)
Article number122
JournalRespiratory Research
Volume11
DOIs
StatePublished - Sep 10 2010

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Chronic Obstructive Pulmonary Disease
Lung
Emphysema
Exercise
Morbidity
Bronchiectasis
Exercise Tolerance
Spirometry
Nutritional Status
Dyspnea
Health Status
Smoking
Tomography

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Agusti, A., Calverley, P. M. A., Celli, B., Coxson, H. O., Edwards, L. D., Lomas, D. A., ... Vestbo, J. (2010). Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respiratory Research, 11, [122]. https://doi.org/10.1186/1465-9921-11-122

Characterisation of COPD heterogeneity in the ECLIPSE cohort. / Agusti, Alvar; Calverley, Peter M.A.; Celli, Bartolome; Coxson, Harvey O.; Edwards, Lisa D.; Lomas, David A.; MacNee, William; Miller, Bruce E.; Rennard, Stephen Israel; Silverman, Edwin K.; Tal-Singer, Ruth; Wouters, Emiel; Yates, Julie C.; Vestbo, Jørgen.

In: Respiratory Research, Vol. 11, 122, 10.09.2010.

Research output: Contribution to journalArticle

Agusti, A, Calverley, PMA, Celli, B, Coxson, HO, Edwards, LD, Lomas, DA, MacNee, W, Miller, BE, Rennard, SI, Silverman, EK, Tal-Singer, R, Wouters, E, Yates, JC & Vestbo, J 2010, 'Characterisation of COPD heterogeneity in the ECLIPSE cohort', Respiratory Research, vol. 11, 122. https://doi.org/10.1186/1465-9921-11-122
Agusti A, Calverley PMA, Celli B, Coxson HO, Edwards LD, Lomas DA et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respiratory Research. 2010 Sep 10;11. 122. https://doi.org/10.1186/1465-9921-11-122
Agusti, Alvar ; Calverley, Peter M.A. ; Celli, Bartolome ; Coxson, Harvey O. ; Edwards, Lisa D. ; Lomas, David A. ; MacNee, William ; Miller, Bruce E. ; Rennard, Stephen Israel ; Silverman, Edwin K. ; Tal-Singer, Ruth ; Wouters, Emiel ; Yates, Julie C. ; Vestbo, Jørgen. / Characterisation of COPD heterogeneity in the ECLIPSE cohort. In: Respiratory Research. 2010 ; Vol. 11.
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AU - Lomas, David A.

AU - MacNee, William

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