Changes in the surface of the mouse blastocyst at implantation.

M. I. Sherman, R. Shalgi, A Angie Rizzino, M. H. Sellens, S. Gay, R. Gay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Implantation is a critical event, and perhaps the earliest one, in the maternal recognition of pregnancy. Information transfer from conceptus to mother might occur during, and subsequent to, implantation at the level of cell surface interaction. Therefore, attempts have been made both to identify the phases of implantation during which changes in the blastocyst surface occur and to characterized such changes. In vitro, blastocysts have been found to go through a series of discrete steps which are analogous to implantation in utero, and these steps can be retarded or prevented by the use of either suboptimal culture media or an inappropriate substratum. Morphological surface changes are not apparent when the blastocyst becomes adherent to the substratum; however, marked differences in blastocyst surface structure are revealed by scanning electron microscopy at the onset of trophoblast outgrowth. Studies at the molecular level implicate collagen as having a role in blastocyst adhesiveness, but other cell surface components are also likely to be involved.

Original languageEnglish (US)
Pages (from-to)33-52
Number of pages20
JournalCiba Foundation symposium
Issue number64
StatePublished - Dec 1 1978

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Blastocyst
Adhesiveness
Trophoblasts
Cellular Structures
Cell Communication
Electron Scanning Microscopy
Culture Media
Collagen
Mothers
Pregnancy

ASJC Scopus subject areas

  • General

Cite this

Sherman, M. I., Shalgi, R., Rizzino, A. A., Sellens, M. H., Gay, S., & Gay, R. (1978). Changes in the surface of the mouse blastocyst at implantation. Ciba Foundation symposium, (64), 33-52.

Changes in the surface of the mouse blastocyst at implantation. / Sherman, M. I.; Shalgi, R.; Rizzino, A Angie; Sellens, M. H.; Gay, S.; Gay, R.

In: Ciba Foundation symposium, No. 64, 01.12.1978, p. 33-52.

Research output: Contribution to journalArticle

Sherman, MI, Shalgi, R, Rizzino, AA, Sellens, MH, Gay, S & Gay, R 1978, 'Changes in the surface of the mouse blastocyst at implantation.', Ciba Foundation symposium, no. 64, pp. 33-52.
Sherman MI, Shalgi R, Rizzino AA, Sellens MH, Gay S, Gay R. Changes in the surface of the mouse blastocyst at implantation. Ciba Foundation symposium. 1978 Dec 1;(64):33-52.
Sherman, M. I. ; Shalgi, R. ; Rizzino, A Angie ; Sellens, M. H. ; Gay, S. ; Gay, R. / Changes in the surface of the mouse blastocyst at implantation. In: Ciba Foundation symposium. 1978 ; No. 64. pp. 33-52.
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