Changes in the pathogenesis of alcohol-induced liver disease - Preclinical studies

Manuela G. Neuman, Samuel W. French, Carol A Casey, Kusum Kharbanda, Radu M. Nanau, Karuna Rasineni, Benita L McVicker, Vincent Kong, Terrence Donohue

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Excessive alcohol consumption presents considerable health risks in humans. A variety of morphologic and functional changes contribute to hepatic injury produced by heavy drinking. The present review summarizes the current knowledge of alcohol-induced liver disease and describes preclinical experimental approaches used to understand alcoholic liver disease (ALD), with a particular emphasis on impaired protein and lipid trafficking, disruption of proteolysis and autophagy, alterations in methionine metabolism and perturbations in metabolic signaling that cause dysfunctional gene expression and the eventual formation of aggresomal Mallory-Denk bodies (MDB) in liver cells. These changes eventually lead to some of the more severe hepatic impairments, including alcoholic hepatitis and fibrosis. Moreover the misuse of alcohol contributes to immune dysfunction and inadequate immune response to viral infections.

Original languageEnglish (US)
Pages (from-to)376-384
Number of pages9
JournalExperimental and Molecular Pathology
Volume95
Issue number3
DOIs
Publication statusPublished - Dec 1 2013

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Keywords

  • Alcohol metabolism
  • In vitro model for alcohol-induced co-morbidities
  • Mallory-Denk bodies
  • Methionine metabolism
  • Protein and lipid traffic

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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