Changes in body composition in patients with chronic obstructive pulmonary disease

Do they influence patient-related outcomes?

Erica P.A. Rutten, Peter M.A. Calverley, Richard Casaburi, Alvar Agusti, Per Bakke, Bartolome Celli, Harvey O. Coxson, Courtney Crim, David A. Lomas, William Macnee, Bruce E. Miller, Stephen Israel Rennard, Paul D. Scanlon, Edwin K. Silverman, Ruth Tal-Singer, Jørgen Vestbo, Michael L. Watkins, Emiel F.M. Wouters

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalAnnals of Nutrition and Metabolism
Volume63
Issue number3
DOIs
StatePublished - Jan 1 2013

Fingerprint

Body Composition
Chronic Obstructive Pulmonary Disease
Fats
Health Status
Mortality
Thinness
Muscles
Longitudinal Studies
Disease Progression
Smoking
Prospective Studies

Keywords

  • Body composition
  • Chronic obstructive pulmonary disease
  • Fat free mass index
  • Fat mass index
  • Health status
  • Mortality

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Rutten, E. P. A., Calverley, P. M. A., Casaburi, R., Agusti, A., Bakke, P., Celli, B., ... Wouters, E. F. M. (2013). Changes in body composition in patients with chronic obstructive pulmonary disease: Do they influence patient-related outcomes? Annals of Nutrition and Metabolism, 63(3), 239-247. https://doi.org/10.1159/000353211

Changes in body composition in patients with chronic obstructive pulmonary disease : Do they influence patient-related outcomes? / Rutten, Erica P.A.; Calverley, Peter M.A.; Casaburi, Richard; Agusti, Alvar; Bakke, Per; Celli, Bartolome; Coxson, Harvey O.; Crim, Courtney; Lomas, David A.; Macnee, William; Miller, Bruce E.; Rennard, Stephen Israel; Scanlon, Paul D.; Silverman, Edwin K.; Tal-Singer, Ruth; Vestbo, Jørgen; Watkins, Michael L.; Wouters, Emiel F.M.

In: Annals of Nutrition and Metabolism, Vol. 63, No. 3, 01.01.2013, p. 239-247.

Research output: Contribution to journalArticle

Rutten, EPA, Calverley, PMA, Casaburi, R, Agusti, A, Bakke, P, Celli, B, Coxson, HO, Crim, C, Lomas, DA, Macnee, W, Miller, BE, Rennard, SI, Scanlon, PD, Silverman, EK, Tal-Singer, R, Vestbo, J, Watkins, ML & Wouters, EFM 2013, 'Changes in body composition in patients with chronic obstructive pulmonary disease: Do they influence patient-related outcomes?', Annals of Nutrition and Metabolism, vol. 63, no. 3, pp. 239-247. https://doi.org/10.1159/000353211
Rutten, Erica P.A. ; Calverley, Peter M.A. ; Casaburi, Richard ; Agusti, Alvar ; Bakke, Per ; Celli, Bartolome ; Coxson, Harvey O. ; Crim, Courtney ; Lomas, David A. ; Macnee, William ; Miller, Bruce E. ; Rennard, Stephen Israel ; Scanlon, Paul D. ; Silverman, Edwin K. ; Tal-Singer, Ruth ; Vestbo, Jørgen ; Watkins, Michael L. ; Wouters, Emiel F.M. / Changes in body composition in patients with chronic obstructive pulmonary disease : Do they influence patient-related outcomes?. In: Annals of Nutrition and Metabolism. 2013 ; Vol. 63, No. 3. pp. 239-247.
@article{d2bf9878838144e0a75f202210c7969f,
title = "Changes in body composition in patients with chronic obstructive pulmonary disease: Do they influence patient-related outcomes?",
abstract = "Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.",
keywords = "Body composition, Chronic obstructive pulmonary disease, Fat free mass index, Fat mass index, Health status, Mortality",
author = "Rutten, {Erica P.A.} and Calverley, {Peter M.A.} and Richard Casaburi and Alvar Agusti and Per Bakke and Bartolome Celli and Coxson, {Harvey O.} and Courtney Crim and Lomas, {David A.} and William Macnee and Miller, {Bruce E.} and Rennard, {Stephen Israel} and Scanlon, {Paul D.} and Silverman, {Edwin K.} and Ruth Tal-Singer and J{\o}rgen Vestbo and Watkins, {Michael L.} and Wouters, {Emiel F.M.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1159/000353211",
language = "English (US)",
volume = "63",
pages = "239--247",
journal = "Annals of Nutrition and Metabolism",
issn = "0250-6807",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Changes in body composition in patients with chronic obstructive pulmonary disease

T2 - Do they influence patient-related outcomes?

AU - Rutten, Erica P.A.

AU - Calverley, Peter M.A.

AU - Casaburi, Richard

AU - Agusti, Alvar

AU - Bakke, Per

AU - Celli, Bartolome

AU - Coxson, Harvey O.

AU - Crim, Courtney

AU - Lomas, David A.

AU - Macnee, William

AU - Miller, Bruce E.

AU - Rennard, Stephen Israel

AU - Scanlon, Paul D.

AU - Silverman, Edwin K.

AU - Tal-Singer, Ruth

AU - Vestbo, Jørgen

AU - Watkins, Michael L.

AU - Wouters, Emiel F.M.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.

AB - Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.

KW - Body composition

KW - Chronic obstructive pulmonary disease

KW - Fat free mass index

KW - Fat mass index

KW - Health status

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=84890521927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890521927&partnerID=8YFLogxK

U2 - 10.1159/000353211

DO - 10.1159/000353211

M3 - Article

VL - 63

SP - 239

EP - 247

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

IS - 3

ER -