Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

for the Investigators of the ADAPT Study

Research output: Contribution to journalArticle

10 Scopus citations


Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

Original languageEnglish (US)
Pages (from-to)1663-1667
Number of pages5
JournalChild's Nervous System
Issue number10
StatePublished - Oct 1 2017



  • Children
  • Comparative effectiveness research
  • Evidenced-based guidelines
  • Pediatric neurocritical care
  • Pediatric neurotrauma
  • Severe traumatic brain injury

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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