Challenges and lessons learned in conducting comparative-effectiveness trials

Linda M Herrick, G. Richard Locke, Alan R. Zinsmeister, Nicholas J. Talley

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The current health-care environment is demanding evidence-based medicine that relies on clinical trials as the basis for decisions. Clinician investigators are more often finding that they are personally responsible for coordinating large, multisite trials. We present strategies for successful implementation and management of multisite clinical trials and knowledge gained through an international, multisite randomized clinical trial. Topics include team composition, regulatory requirements, study organization and governance, communication strategies, recruitment and retention efforts, budget, technology transfer, and publication.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume107
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Clinical Trials
Technology Transfer
Evidence-Based Medicine
Budgets
Publications
Randomized Controlled Trials
Research Personnel
Organizations
Delivery of Health Care

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Challenges and lessons learned in conducting comparative-effectiveness trials. / Herrick, Linda M; Locke, G. Richard; Zinsmeister, Alan R.; Talley, Nicholas J.

In: American Journal of Gastroenterology, Vol. 107, No. 5, 01.05.2012, p. 644-649.

Research output: Contribution to journalReview article

Herrick, Linda M ; Locke, G. Richard ; Zinsmeister, Alan R. ; Talley, Nicholas J. / Challenges and lessons learned in conducting comparative-effectiveness trials. In: American Journal of Gastroenterology. 2012 ; Vol. 107, No. 5. pp. 644-649.
@article{727eab9850dd48e3b2842c41bf7cbade,
title = "Challenges and lessons learned in conducting comparative-effectiveness trials",
abstract = "The current health-care environment is demanding evidence-based medicine that relies on clinical trials as the basis for decisions. Clinician investigators are more often finding that they are personally responsible for coordinating large, multisite trials. We present strategies for successful implementation and management of multisite clinical trials and knowledge gained through an international, multisite randomized clinical trial. Topics include team composition, regulatory requirements, study organization and governance, communication strategies, recruitment and retention efforts, budget, technology transfer, and publication.",
author = "Herrick, {Linda M} and Locke, {G. Richard} and Zinsmeister, {Alan R.} and Talley, {Nicholas J.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1038/ajg.2011.475",
language = "English (US)",
volume = "107",
pages = "644--649",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Challenges and lessons learned in conducting comparative-effectiveness trials

AU - Herrick, Linda M

AU - Locke, G. Richard

AU - Zinsmeister, Alan R.

AU - Talley, Nicholas J.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - The current health-care environment is demanding evidence-based medicine that relies on clinical trials as the basis for decisions. Clinician investigators are more often finding that they are personally responsible for coordinating large, multisite trials. We present strategies for successful implementation and management of multisite clinical trials and knowledge gained through an international, multisite randomized clinical trial. Topics include team composition, regulatory requirements, study organization and governance, communication strategies, recruitment and retention efforts, budget, technology transfer, and publication.

AB - The current health-care environment is demanding evidence-based medicine that relies on clinical trials as the basis for decisions. Clinician investigators are more often finding that they are personally responsible for coordinating large, multisite trials. We present strategies for successful implementation and management of multisite clinical trials and knowledge gained through an international, multisite randomized clinical trial. Topics include team composition, regulatory requirements, study organization and governance, communication strategies, recruitment and retention efforts, budget, technology transfer, and publication.

UR - http://www.scopus.com/inward/record.url?scp=84862305307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862305307&partnerID=8YFLogxK

U2 - 10.1038/ajg.2011.475

DO - 10.1038/ajg.2011.475

M3 - Review article

VL - 107

SP - 644

EP - 649

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 5

ER -