cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter

Scott A Nawy, Craig E. Jahr

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Transmitter release from photoreceptors is decreased by light, resulting in a conductance increase in depolarizing bipolar cells. Addition of exogenous cGMP through a patch pipette to depolarizing bipolar cells from slices of dark-adapted tiger salamander retina resulted in an enhancement of the light response. This enhancement was blocked by GTP-γ-S and dipyridamole, an inhibitor of phosphodiesterase. GTP-γ-S and dipyridamole also blocked responses to exogenously applied 2-amino-4-phosphonobutyrate (APB), the glutamate agonist selective for this receptor. These data support the hypothesis that the postsynaptic receptor is linked via a G protein to a phosphodiesterase. The binding of glutamate or APB to the receptor suppresses a cGMP-activated current by increasing the rate of cyclic nucleotide hydrolysis.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalNeuron
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1991

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Retinal Bipolar Cells
Dipyridamole
Guanosine Triphosphate
Ambystoma
Excitatory Amino Acid Agonists
Light
Phosphodiesterase Inhibitors
Cyclic Nucleotides
Phosphoric Diester Hydrolases
GTP-Binding Proteins
Retina
Glutamic Acid
Hydrolysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. / Nawy, Scott A; Jahr, Craig E.

In: Neuron, Vol. 7, No. 4, 01.01.1991, p. 677-683.

Research output: Contribution to journalArticle

Nawy, Scott A ; Jahr, Craig E. / cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. In: Neuron. 1991 ; Vol. 7, No. 4. pp. 677-683.
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