Cervical cancer control, priorities and new directions

Joseph Monsonego, F. Xavier Bosch, Pierre Coursaget, John Thomas Cox, Eduardo Franco, Ian Frazer, Rengaswamy Sankaranarayanan, John Schiller, Albert Singer, Tom Wright, Walter Kinney, Chris Meijer, James Linder

98 Scopus citations

Abstract

Cervical cancer is caused by infection with a range of high risk "oncogenic" human papillomavirus (HPV) types, and it is now accepted that >99% of cervical cancer is initiated by HPV infection. The estimated lifetime risk of cervical cancer is nevertheless relatively low (less than 1 in 20 for most community based studies). Although sensitivity and specificity of the available diagnostic techniques are suboptimal, screening for persistent HPV infection is effective in reducing the incidence of cervical cancer. Infection can be detected by molecular techniques or by cytological examination of exfoliated cervical cells. Persistent infection is the single best predictor of risk of cervical cancer. The latest findings of HPV and cervical cancer research need to be widely disseminated to the scientific and medical societies that are updating screening and management protocols, public health professionals, and to women and clinicians. This report reviews current evidence, clinical implications and directions for further research in the prevention, control and management of cervical cancer. We report the conclusions of the Experts' Meeting at the EUROGIN 2003 conference.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalInternational Journal of Cancer
Volume108
Issue number3
DOIs
Publication statusPublished - Jan 20 2004

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Keywords

  • Cervical neoplasia
  • Colposcopy
  • HPV vaccine
  • Human papillomavirus
  • Screening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Monsonego, J., Bosch, F. X., Coursaget, P., Cox, J. T., Franco, E., Frazer, I., ... Linder, J. (2004). Cervical cancer control, priorities and new directions. International Journal of Cancer, 108(3), 329-333. https://doi.org/10.1002/ijc.11530