Cerebral structural abnormalities in obsessive-compulsive disorder: A quantitative morphometric magnetic resonance imaging study

Michael A. Jenike, Hans C. Breiter, Lee Baer, David N. Kennedy, Cary R. Savage, Michael J. Olivares, Richard L. O'Sullivan, David M. Shera, Scott L. Rauch, Nancy Keuthen, Bruce R. Rosen, Verne S. Caviness, Pauline A. Filipek

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Background: A previous pilot study of only posterior brain regions found lower white-matter volume in patients with obsessive-compulsive disorder than in normal control subjects. We used new cohorts of patients and matched normal control subjects to study whole-brain volume differences between these groups with magnetic resonance imaging-based morphometry. Methods: Ten female patients with obsessive-compulsive disorder and 10 female control subjects, matched for handedness, age, weight, education, and verbal IQ, underwent magnetic resonance imaging with a 3-dimensional volumetric protocol. Scans were blindly normalized and segmented by means of well-characterized semiautomated intensity contour mapping and differential intensity contour algorithms. Brain structures investigated included the cerebral hemispheres, cerebral cortex, diencephalon, caudate, putamen, globus pallidus, hippocampus, amygdala, third and fourth ventricles, corpus callosum, operculum, cerebellum, and brain stem. Anterior to posterior neocortical regions, including precallosum, anterior pericallosum, posterior pericallosum, and retrocallosum, with adjacent white matter were also measured. Volumes found different between groups were correlated with Yale- Brown Obsessive Compulsive Scale score and Rey-Osterieth Complex Figure Test measures. Results: Confirming results of our earlier pilot study and expanding the findings to the whole brain, patients with obsessive-compulsive disorder had significantly less total white matter but, in addition, significantly greater total cortex and opercular volumes. Severity of obsessive-compulsive disorder and nonverbal immediate memory correlated with opercular volume. Conclusions: Replication of volumetric white-matter differences suggests a widely distributed structural brain abnormality in obsessive-compulsive disorder. Whereas determining the etiogenesis may require research at a microscopic level, understanding its functional significance can be further explored via functional neuroimaging and neuropsychological studies.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalArchives of general psychiatry
Volume53
Issue number7
DOIs
StatePublished - Jan 1 1996

Fingerprint

Obsessive-Compulsive Disorder
Magnetic Resonance Imaging
Brain
Fourth Ventricle
Diencephalon
Functional Neuroimaging
Functional Laterality
Third Ventricle
Globus Pallidus
Corpus Callosum
Putamen
Cerebrum
Amygdala
Short-Term Memory
Cerebral Cortex
Cerebellum
Brain Stem
Hippocampus
Morphometrics
Obsessive-compulsive Disorder

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Cerebral structural abnormalities in obsessive-compulsive disorder : A quantitative morphometric magnetic resonance imaging study. / Jenike, Michael A.; Breiter, Hans C.; Baer, Lee; Kennedy, David N.; Savage, Cary R.; Olivares, Michael J.; O'Sullivan, Richard L.; Shera, David M.; Rauch, Scott L.; Keuthen, Nancy; Rosen, Bruce R.; Caviness, Verne S.; Filipek, Pauline A.

In: Archives of general psychiatry, Vol. 53, No. 7, 01.01.1996, p. 625-632.

Research output: Contribution to journalArticle

Jenike, MA, Breiter, HC, Baer, L, Kennedy, DN, Savage, CR, Olivares, MJ, O'Sullivan, RL, Shera, DM, Rauch, SL, Keuthen, N, Rosen, BR, Caviness, VS & Filipek, PA 1996, 'Cerebral structural abnormalities in obsessive-compulsive disorder: A quantitative morphometric magnetic resonance imaging study', Archives of general psychiatry, vol. 53, no. 7, pp. 625-632. https://doi.org/10.1001/archpsyc.1996.01830070073011
Jenike, Michael A. ; Breiter, Hans C. ; Baer, Lee ; Kennedy, David N. ; Savage, Cary R. ; Olivares, Michael J. ; O'Sullivan, Richard L. ; Shera, David M. ; Rauch, Scott L. ; Keuthen, Nancy ; Rosen, Bruce R. ; Caviness, Verne S. ; Filipek, Pauline A. / Cerebral structural abnormalities in obsessive-compulsive disorder : A quantitative morphometric magnetic resonance imaging study. In: Archives of general psychiatry. 1996 ; Vol. 53, No. 7. pp. 625-632.
@article{7a6ea34d59924b18813b51eb0f3f5a56,
title = "Cerebral structural abnormalities in obsessive-compulsive disorder: A quantitative morphometric magnetic resonance imaging study",
abstract = "Background: A previous pilot study of only posterior brain regions found lower white-matter volume in patients with obsessive-compulsive disorder than in normal control subjects. We used new cohorts of patients and matched normal control subjects to study whole-brain volume differences between these groups with magnetic resonance imaging-based morphometry. Methods: Ten female patients with obsessive-compulsive disorder and 10 female control subjects, matched for handedness, age, weight, education, and verbal IQ, underwent magnetic resonance imaging with a 3-dimensional volumetric protocol. Scans were blindly normalized and segmented by means of well-characterized semiautomated intensity contour mapping and differential intensity contour algorithms. Brain structures investigated included the cerebral hemispheres, cerebral cortex, diencephalon, caudate, putamen, globus pallidus, hippocampus, amygdala, third and fourth ventricles, corpus callosum, operculum, cerebellum, and brain stem. Anterior to posterior neocortical regions, including precallosum, anterior pericallosum, posterior pericallosum, and retrocallosum, with adjacent white matter were also measured. Volumes found different between groups were correlated with Yale- Brown Obsessive Compulsive Scale score and Rey-Osterieth Complex Figure Test measures. Results: Confirming results of our earlier pilot study and expanding the findings to the whole brain, patients with obsessive-compulsive disorder had significantly less total white matter but, in addition, significantly greater total cortex and opercular volumes. Severity of obsessive-compulsive disorder and nonverbal immediate memory correlated with opercular volume. Conclusions: Replication of volumetric white-matter differences suggests a widely distributed structural brain abnormality in obsessive-compulsive disorder. Whereas determining the etiogenesis may require research at a microscopic level, understanding its functional significance can be further explored via functional neuroimaging and neuropsychological studies.",
author = "Jenike, {Michael A.} and Breiter, {Hans C.} and Lee Baer and Kennedy, {David N.} and Savage, {Cary R.} and Olivares, {Michael J.} and O'Sullivan, {Richard L.} and Shera, {David M.} and Rauch, {Scott L.} and Nancy Keuthen and Rosen, {Bruce R.} and Caviness, {Verne S.} and Filipek, {Pauline A.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1001/archpsyc.1996.01830070073011",
language = "English (US)",
volume = "53",
pages = "625--632",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Cerebral structural abnormalities in obsessive-compulsive disorder

T2 - A quantitative morphometric magnetic resonance imaging study

AU - Jenike, Michael A.

AU - Breiter, Hans C.

AU - Baer, Lee

AU - Kennedy, David N.

AU - Savage, Cary R.

AU - Olivares, Michael J.

AU - O'Sullivan, Richard L.

AU - Shera, David M.

AU - Rauch, Scott L.

AU - Keuthen, Nancy

AU - Rosen, Bruce R.

AU - Caviness, Verne S.

AU - Filipek, Pauline A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Background: A previous pilot study of only posterior brain regions found lower white-matter volume in patients with obsessive-compulsive disorder than in normal control subjects. We used new cohorts of patients and matched normal control subjects to study whole-brain volume differences between these groups with magnetic resonance imaging-based morphometry. Methods: Ten female patients with obsessive-compulsive disorder and 10 female control subjects, matched for handedness, age, weight, education, and verbal IQ, underwent magnetic resonance imaging with a 3-dimensional volumetric protocol. Scans were blindly normalized and segmented by means of well-characterized semiautomated intensity contour mapping and differential intensity contour algorithms. Brain structures investigated included the cerebral hemispheres, cerebral cortex, diencephalon, caudate, putamen, globus pallidus, hippocampus, amygdala, third and fourth ventricles, corpus callosum, operculum, cerebellum, and brain stem. Anterior to posterior neocortical regions, including precallosum, anterior pericallosum, posterior pericallosum, and retrocallosum, with adjacent white matter were also measured. Volumes found different between groups were correlated with Yale- Brown Obsessive Compulsive Scale score and Rey-Osterieth Complex Figure Test measures. Results: Confirming results of our earlier pilot study and expanding the findings to the whole brain, patients with obsessive-compulsive disorder had significantly less total white matter but, in addition, significantly greater total cortex and opercular volumes. Severity of obsessive-compulsive disorder and nonverbal immediate memory correlated with opercular volume. Conclusions: Replication of volumetric white-matter differences suggests a widely distributed structural brain abnormality in obsessive-compulsive disorder. Whereas determining the etiogenesis may require research at a microscopic level, understanding its functional significance can be further explored via functional neuroimaging and neuropsychological studies.

AB - Background: A previous pilot study of only posterior brain regions found lower white-matter volume in patients with obsessive-compulsive disorder than in normal control subjects. We used new cohorts of patients and matched normal control subjects to study whole-brain volume differences between these groups with magnetic resonance imaging-based morphometry. Methods: Ten female patients with obsessive-compulsive disorder and 10 female control subjects, matched for handedness, age, weight, education, and verbal IQ, underwent magnetic resonance imaging with a 3-dimensional volumetric protocol. Scans were blindly normalized and segmented by means of well-characterized semiautomated intensity contour mapping and differential intensity contour algorithms. Brain structures investigated included the cerebral hemispheres, cerebral cortex, diencephalon, caudate, putamen, globus pallidus, hippocampus, amygdala, third and fourth ventricles, corpus callosum, operculum, cerebellum, and brain stem. Anterior to posterior neocortical regions, including precallosum, anterior pericallosum, posterior pericallosum, and retrocallosum, with adjacent white matter were also measured. Volumes found different between groups were correlated with Yale- Brown Obsessive Compulsive Scale score and Rey-Osterieth Complex Figure Test measures. Results: Confirming results of our earlier pilot study and expanding the findings to the whole brain, patients with obsessive-compulsive disorder had significantly less total white matter but, in addition, significantly greater total cortex and opercular volumes. Severity of obsessive-compulsive disorder and nonverbal immediate memory correlated with opercular volume. Conclusions: Replication of volumetric white-matter differences suggests a widely distributed structural brain abnormality in obsessive-compulsive disorder. Whereas determining the etiogenesis may require research at a microscopic level, understanding its functional significance can be further explored via functional neuroimaging and neuropsychological studies.

UR - http://www.scopus.com/inward/record.url?scp=8944252808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8944252808&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1996.01830070073011

DO - 10.1001/archpsyc.1996.01830070073011

M3 - Article

C2 - 8660129

AN - SCOPUS:8944252808

VL - 53

SP - 625

EP - 632

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 7

ER -