Cerebral oedema and increased intracranial pressure in chronic liver disease

Jeremiah P. Donovan, Daniel Francis Schafer, Byers W. Shaw, Michael Floyd Sorrell

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Background: Cerebral oedema is a cause of morbidity and mortality in fulminant hepatic failure but has not been well documented as a complication of chronic liver diseases. We report here the development of cerebral oedema and increased intracranial pressure in 12 patients with chronic liver disease. Methods: Between July 1, 1987, and Dec 31, 1993, we studied 12 patients aged 29-67 years with end-stage chronic liver disease. All the patients had cirrhosis, portal hypertension, hypoprothrombinaemia, hepatic encephalopathy, and decreased serum concentrations of albumin (< 25 g/L). During the study, the patients developed signs of increased intracranial pressure and had documented intracranial hypertension, cerebral oedema, or both. Intracranial hypertension was suspected on physical examination and confirmed by epidural catheters. We detected cerebral oedema by computed axial tomography of the head and necropsy of the brain when possible. Findings: All the patients had intracranial hypertension and cerebral oedema. Two patients had successful treatment of cerebral hypertension with improvement of intracranial pressure such that orthotopic liver transplantation was undertaken. Both patients became neurologically normal after transplantation. Eight patients had only a transient reponse to treatment and died of cerebral oedema before a transplant could be done. Interpretation: Cerebral oedema and increased intracranial pressure can occur in chronic liver disease and presents as neurological deterioration. Treatment guided by monitoring of intracranial pressure can lead to the reversal of intracranial hypertension, but in most patients cerebral oedema contributes to death or places them at too high a risk for liver transplantation.

Original languageEnglish (US)
Pages (from-to)719-721
Number of pages3
JournalLancet
Volume351
Issue number9104
DOIs
StatePublished - Mar 7 1998

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Brain Edema
Intracranial Pressure
Liver Diseases
Chronic Disease
Intracranial Hypertension
Liver Transplantation
Hypoprothrombinemias
End Stage Liver Disease
Hepatic Encephalopathy
Acute Liver Failure
Portal Hypertension
Serum Albumin
Physical Examination
Fibrosis
Therapeutics
Catheters
Transplantation
Head
Tomography
Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cerebral oedema and increased intracranial pressure in chronic liver disease. / Donovan, Jeremiah P.; Schafer, Daniel Francis; Shaw, Byers W.; Sorrell, Michael Floyd.

In: Lancet, Vol. 351, No. 9104, 07.03.1998, p. 719-721.

Research output: Contribution to journalArticle

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