Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor

Sakthivel Muniyan, Matthew A. Ingersoll, Surinder Kumar Batra, Ming-Fong Lin

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The inactivation of tumor suppressor genes (TSGs) plays a vital role in the progression of human cancers. Nevertheless, those ubiquitous TSGs have been shown with limited roles in various stages of diverse carcinogenesis. Investigation on identifying unique TSG, especially for early stage of carcinogenesis, is imperative. As such, the search for organ-specific TSGs has emerged as a major strategy in cancer research. Prostate cancer (PCa) has the highest incidence in solid tumors in US males. Cellular prostatic acid phosphatase (cPAcP) is a prostate-specific differentiation antigen. Despite intensive studies over the past several decades on PAcP as a PCa biomarker, the role of cPAcP as a PCa-specific tumor suppressor has only recently been emerged and validated. The mechanism underlying the pivotal role of cPAcP as a prostate-specific TSG is, in part, due to its function as a protein tyrosine phosphatase (PTP) as well as a phosphoinositide phosphatase (PIP), an apparent functional homologue to phosphatase and tensin homolog (PTEN) in PCa cells. This review is focused on discussing the function of this authentic prostate-specific tumor suppressor and the mechanism behind the loss of cPAcP expression leading to prostate carcinogenesis. We review other phosphatases' roles as TSGs which regulate oncogenic PI3K signaling in PCa and discuss the functional similarity between cPAcP and PTEN in prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)88-98
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1846
Issue number1
DOIs
StatePublished - Aug 2014

Fingerprint

Tumor Suppressor Genes
Phosphoric Monoester Hydrolases
Prostate
Epithelium
Prostatic Neoplasms
Carcinogenesis
Neoplasms
Protein Tyrosine Phosphatases
Differentiation Antigens
Prostate-Specific Antigen
Tumor Biomarkers
Phosphatidylinositol 3-Kinases
Tensins
prostatic acid phosphatase
Incidence
Research

Keywords

  • CPAcP
  • ErbB-2
  • Phosphoinositide phosphatase
  • Prostate cancer
  • Protein tyrosine phosphatase
  • Tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

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title = "Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor",
abstract = "The inactivation of tumor suppressor genes (TSGs) plays a vital role in the progression of human cancers. Nevertheless, those ubiquitous TSGs have been shown with limited roles in various stages of diverse carcinogenesis. Investigation on identifying unique TSG, especially for early stage of carcinogenesis, is imperative. As such, the search for organ-specific TSGs has emerged as a major strategy in cancer research. Prostate cancer (PCa) has the highest incidence in solid tumors in US males. Cellular prostatic acid phosphatase (cPAcP) is a prostate-specific differentiation antigen. Despite intensive studies over the past several decades on PAcP as a PCa biomarker, the role of cPAcP as a PCa-specific tumor suppressor has only recently been emerged and validated. The mechanism underlying the pivotal role of cPAcP as a prostate-specific TSG is, in part, due to its function as a protein tyrosine phosphatase (PTP) as well as a phosphoinositide phosphatase (PIP), an apparent functional homologue to phosphatase and tensin homolog (PTEN) in PCa cells. This review is focused on discussing the function of this authentic prostate-specific tumor suppressor and the mechanism behind the loss of cPAcP expression leading to prostate carcinogenesis. We review other phosphatases' roles as TSGs which regulate oncogenic PI3K signaling in PCa and discuss the functional similarity between cPAcP and PTEN in prostate carcinogenesis.",
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author = "Sakthivel Muniyan and Ingersoll, {Matthew A.} and Batra, {Surinder Kumar} and Ming-Fong Lin",
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AU - Lin, Ming-Fong

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