Cellular-level surgery using nano robots

Bo Song, Ruiguo Yang, Ning Xi, Kevin Charles Patterson, Chengeng Qu, King Wai Chiu Lai

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.

Original languageEnglish (US)
Pages (from-to)425-434
Number of pages10
JournalJournal of Laboratory Automation
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Surgery
Robots
Microscopes
Sensory Feedback
Aptitude
Imaging techniques
Mechanical properties
Software
Observation
Bacteria
User interfaces
Capacitance
Pharmaceutical Preparations
Feedback
Monitoring

Keywords

  • AFM
  • Cellular-level surgery
  • Multifunctions
  • Nano robot

ASJC Scopus subject areas

  • Computer Science Applications
  • Medical Laboratory Technology

Cite this

Song, B., Yang, R., Xi, N., Patterson, K. C., Qu, C., & Lai, K. W. C. (2012). Cellular-level surgery using nano robots. Journal of Laboratory Automation, 17(6), 425-434. https://doi.org/10.1177/2211068212460665

Cellular-level surgery using nano robots. / Song, Bo; Yang, Ruiguo; Xi, Ning; Patterson, Kevin Charles; Qu, Chengeng; Lai, King Wai Chiu.

In: Journal of Laboratory Automation, Vol. 17, No. 6, 01.12.2012, p. 425-434.

Research output: Contribution to journalArticle

Song, B, Yang, R, Xi, N, Patterson, KC, Qu, C & Lai, KWC 2012, 'Cellular-level surgery using nano robots', Journal of Laboratory Automation, vol. 17, no. 6, pp. 425-434. https://doi.org/10.1177/2211068212460665
Song, Bo ; Yang, Ruiguo ; Xi, Ning ; Patterson, Kevin Charles ; Qu, Chengeng ; Lai, King Wai Chiu. / Cellular-level surgery using nano robots. In: Journal of Laboratory Automation. 2012 ; Vol. 17, No. 6. pp. 425-434.
@article{188b7aa2f491466488dec1c1051ef7a4,
title = "Cellular-level surgery using nano robots",
abstract = "The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a {"}videolized{"} visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.",
keywords = "AFM, Cellular-level surgery, Multifunctions, Nano robot",
author = "Bo Song and Ruiguo Yang and Ning Xi and Patterson, {Kevin Charles} and Chengeng Qu and Lai, {King Wai Chiu}",
year = "2012",
month = "12",
day = "1",
doi = "10.1177/2211068212460665",
language = "English (US)",
volume = "17",
pages = "425--434",
journal = "JALA - Journal of the Association for Laboratory Automation",
issn = "1535-5535",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Cellular-level surgery using nano robots

AU - Song, Bo

AU - Yang, Ruiguo

AU - Xi, Ning

AU - Patterson, Kevin Charles

AU - Qu, Chengeng

AU - Lai, King Wai Chiu

PY - 2012/12/1

Y1 - 2012/12/1

N2 - The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.

AB - The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.

KW - AFM

KW - Cellular-level surgery

KW - Multifunctions

KW - Nano robot

UR - http://www.scopus.com/inward/record.url?scp=84875692791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875692791&partnerID=8YFLogxK

U2 - 10.1177/2211068212460665

DO - 10.1177/2211068212460665

M3 - Article

C2 - 23015517

AN - SCOPUS:84875692791

VL - 17

SP - 425

EP - 434

JO - JALA - Journal of the Association for Laboratory Automation

JF - JALA - Journal of the Association for Laboratory Automation

SN - 1535-5535

IS - 6

ER -