Cellular and viral determinants that regulate HIV-1 infection in macrophages

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediated immune responses that regulate the levels of infection and lead to viral persistence. HIV determinants control viral entry and productive replication and, taken together with cellular differentiation factors, decide the outcome of virus-macrophage interactions. Most important, many clinical manifestations of HIV infection such as encephalitis, myelopathy, pneumonitis, and lymphadenopathy are closely linked to viral replication. Indeed, tissue pathology often correlates with viral gene expression in tissue macrophages. Taken together, these observations provide strong support for a central role of macrophages in progressive HIV infection and its clinical manifestations.

Original languageEnglish (US)
Pages (from-to)278-288
Number of pages11
JournalJournal of Leukocyte Biology
Volume56
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

HIV Infections
HIV-1
Macrophages
HIV
Asymptomatic Infections
Viral Genes
Spinal Cord Diseases
Encephalitis
Pneumonia
Pathology
Viruses
T-Lymphocytes
Gene Expression
Lung
Brain
Infection

Keywords

  • HIV-1 cellular reservoirs
  • monocyte/macrophage-HIV-1 interactions
  • viral persistence

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Cellular and viral determinants that regulate HIV-1 infection in macrophages. / Stevenson, M.; Gendelman, Howard Eliot.

In: Journal of Leukocyte Biology, Vol. 56, No. 3, 01.01.1994, p. 278-288.

Research output: Contribution to journalReview article

@article{449c8c058dc448a5a9964dfd8cf42c47,
title = "Cellular and viral determinants that regulate HIV-1 infection in macrophages",
abstract = "Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediated immune responses that regulate the levels of infection and lead to viral persistence. HIV determinants control viral entry and productive replication and, taken together with cellular differentiation factors, decide the outcome of virus-macrophage interactions. Most important, many clinical manifestations of HIV infection such as encephalitis, myelopathy, pneumonitis, and lymphadenopathy are closely linked to viral replication. Indeed, tissue pathology often correlates with viral gene expression in tissue macrophages. Taken together, these observations provide strong support for a central role of macrophages in progressive HIV infection and its clinical manifestations.",
keywords = "HIV-1 cellular reservoirs, monocyte/macrophage-HIV-1 interactions, viral persistence",
author = "M. Stevenson and Gendelman, {Howard Eliot}",
year = "1994",
month = "1",
day = "1",
doi = "10.1002/jlb.56.3.278",
language = "English (US)",
volume = "56",
pages = "278--288",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Cellular and viral determinants that regulate HIV-1 infection in macrophages

AU - Stevenson, M.

AU - Gendelman, Howard Eliot

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediated immune responses that regulate the levels of infection and lead to viral persistence. HIV determinants control viral entry and productive replication and, taken together with cellular differentiation factors, decide the outcome of virus-macrophage interactions. Most important, many clinical manifestations of HIV infection such as encephalitis, myelopathy, pneumonitis, and lymphadenopathy are closely linked to viral replication. Indeed, tissue pathology often correlates with viral gene expression in tissue macrophages. Taken together, these observations provide strong support for a central role of macrophages in progressive HIV infection and its clinical manifestations.

AB - Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediated immune responses that regulate the levels of infection and lead to viral persistence. HIV determinants control viral entry and productive replication and, taken together with cellular differentiation factors, decide the outcome of virus-macrophage interactions. Most important, many clinical manifestations of HIV infection such as encephalitis, myelopathy, pneumonitis, and lymphadenopathy are closely linked to viral replication. Indeed, tissue pathology often correlates with viral gene expression in tissue macrophages. Taken together, these observations provide strong support for a central role of macrophages in progressive HIV infection and its clinical manifestations.

KW - HIV-1 cellular reservoirs

KW - monocyte/macrophage-HIV-1 interactions

KW - viral persistence

UR - http://www.scopus.com/inward/record.url?scp=0028086274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028086274&partnerID=8YFLogxK

U2 - 10.1002/jlb.56.3.278

DO - 10.1002/jlb.56.3.278

M3 - Review article

C2 - 8083600

AN - SCOPUS:0028086274

VL - 56

SP - 278

EP - 288

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 3

ER -