Cell polarity

The missing link in skeletal morphogenesis?

Sarah M. Romereim, Andrew T Dudley

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Despite extensive genetic analysis of the dynamic multi-phase process that transforms a small population of lateral plate mesoderm into the mature limb skeleton, the mechanisms by which signaling pathways regulate cellular behaviors to generate morphogenetic forces are not known. Recently, a series of papers have offered the intriguing possibility that regulated cell polarity fine-tunes the morphogenetic process via orienting cell axes, division planes and cell movements. Wnt5a-mediated non-canonical signaling, which may include planar cell polarity, has emerged as a common thread in the otherwise distinct signaling networks that regulate morphogenesis in each phase of limb development. These findings position the limb as a key model to elucidate how global tissue patterning pathways direct local differences in cell behavior that, in turn, generate growth and form.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalOrganogenesis
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2011

Fingerprint

Cell Polarity
Morphogenesis
Extremities
Mesoderm
Skeleton
Cell Division
Cell Movement
Cells
Tissue
Growth
Population

ASJC Scopus subject areas

  • Embryology
  • Biomedical Engineering
  • Developmental Biology
  • Transplantation

Cite this

Cell polarity : The missing link in skeletal morphogenesis? / Romereim, Sarah M.; Dudley, Andrew T.

In: Organogenesis, Vol. 7, No. 3, 01.01.2011, p. 217-228.

Research output: Contribution to journalReview article

Romereim, Sarah M. ; Dudley, Andrew T. / Cell polarity : The missing link in skeletal morphogenesis?. In: Organogenesis. 2011 ; Vol. 7, No. 3. pp. 217-228.
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