Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis

Research output: Contribution to journalReview article

283 Citations (Scopus)

Abstract

In humans and experimental models of renal ischemia, tubular cells in various nephron segments undergo necrotic and/or apoptotic cell death. Various factors, including nucleotide depletion, electrolyte imbalance, reactive oxygen species, endonucleases, disruption of mitochondrial integrity, and activation of various components of the apoptotic machinery, have been implicated in renal cell vulnerability. Several approaches to limit the injury and augment the regeneration process, including nucleotide repletion, administration of growth factors, reactive oxygen species scavengers, and inhibition of inducers and executioners of cell death, proved to be effective in animal models. Nevertheless, an effective approach to limit or prevent ischemic renal injury in humans remains elusive, primarily because of an incomplete understanding of the mechanisms of cellular injury. Elucidation of cell death pathways in animal models in the setting of renal injury and extrapolation of the findings to humans will aid in the design of potential therapeutic strategies. This review evaluates our understanding of the molecular signaling events in apoptotic and necrotic cell death and the contribution of various molecular components of these pathways to renal injury.

Original languageEnglish (US)
Pages (from-to)F608-F627
JournalAmerican Journal of Physiology - Renal Physiology
Volume284
Issue number4 53-4
StatePublished - Apr 1 2003

Fingerprint

Acute Kidney Injury
Cell Death
Necrosis
Apoptosis
Kidney
Wounds and Injuries
Reactive Oxygen Species
Nucleotides
Animal Models
Endonucleases
Nephrons
Helper-Inducer T-Lymphocytes
Electrolytes
Regeneration
Intercellular Signaling Peptides and Proteins
Theoretical Models
Ischemia
Therapeutics

Keywords

  • Molecular components
  • Renal ischemia
  • Renal tubular epithelial cells
  • Signal transduction
  • Therapeutic approaches

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Cell death induced by acute renal injury : A perspective on the contributions of apoptosis and necrosis. / Padanilam, Babu J.

In: American Journal of Physiology - Renal Physiology, Vol. 284, No. 4 53-4, 01.04.2003, p. F608-F627.

Research output: Contribution to journalReview article

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