Cell culture studies on human nerve sheath tumors

Kusum Kharbanda, Amit K. Dinda, Chitra Sarkar, Asis K. Karak, Meera Mathur, Subimal Roy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The main controversy about nerve sheath tumors (NSTs) has been their histogenesis, A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff 1 observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas consisted of mainly perineurial cells. In addition, variable numbers of fibroblast-like cells and intermediate cells also have been reported in the 2 lesions. Whether these represent distinct cell types or variants of Schwann cells is still debatable. In an attempt to solve this controversy, the present study was undertaken to observe the morphology and the behaviour of these tumors in culture. These studies showed that all nerve sheath tumors are basically of Schwann cell origin and that intermediate cells and fibroblasts are variants of Schwann cell. Tissue culture studies done chiefly on schwannomas showed that the morphological features of schwannomas are preserved in ‘in vitro culture’ condition and therefore the difference between neurofibroma and schwannoma appears to be due to inherent differentiating property of the Schwann cells along with some environmental stimulus.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalPathology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1994

Fingerprint

Nerve Sheath Neoplasms
Schwann Cells
Neurilemmoma
Cell Culture Techniques
Neurofibroma
Fibroblasts
Research Personnel

Keywords

  • Bromodeoxyuridine
  • Immunohistochemistry
  • In vitro culture
  • Intermediate cell
  • Labelling index
  • Nerve sheath tumor
  • Phagocytosis
  • S-100 protein
  • Schwann cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kharbanda, K., Dinda, A. K., Sarkar, C., Karak, A. K., Mathur, M., & Roy, S. (1994). Cell culture studies on human nerve sheath tumors. Pathology, 26(1), 29-32. https://doi.org/10.1080/00313029400169051

Cell culture studies on human nerve sheath tumors. / Kharbanda, Kusum; Dinda, Amit K.; Sarkar, Chitra; Karak, Asis K.; Mathur, Meera; Roy, Subimal.

In: Pathology, Vol. 26, No. 1, 01.01.1994, p. 29-32.

Research output: Contribution to journalArticle

Kharbanda, K, Dinda, AK, Sarkar, C, Karak, AK, Mathur, M & Roy, S 1994, 'Cell culture studies on human nerve sheath tumors', Pathology, vol. 26, no. 1, pp. 29-32. https://doi.org/10.1080/00313029400169051
Kharbanda K, Dinda AK, Sarkar C, Karak AK, Mathur M, Roy S. Cell culture studies on human nerve sheath tumors. Pathology. 1994 Jan 1;26(1):29-32. https://doi.org/10.1080/00313029400169051
Kharbanda, Kusum ; Dinda, Amit K. ; Sarkar, Chitra ; Karak, Asis K. ; Mathur, Meera ; Roy, Subimal. / Cell culture studies on human nerve sheath tumors. In: Pathology. 1994 ; Vol. 26, No. 1. pp. 29-32.
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