CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

Maria Cecilia G Marcondes, Brenda Morsey, Katy Emanuel, Benjamin G. Lamberty, Claudia T. Flynn, Howard S Fox

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalJournal of Infectious Diseases
Volume211
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Simian Immunodeficiency Virus
Central Nervous System
T-Lymphocytes
Brain
Viruses
Virus Diseases
Macaca mulatta
Cerebrospinal Fluid
Immune System
Monoclonal Antibodies
HIV
Infection

Keywords

  • CD8
  • HIV
  • SIV
  • brain
  • cerebrospinal
  • immune.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system. / Marcondes, Maria Cecilia G; Morsey, Brenda; Emanuel, Katy; Lamberty, Benjamin G.; Flynn, Claudia T.; Fox, Howard S.

In: Journal of Infectious Diseases, Vol. 211, No. 1, 01.01.2015, p. 40-44.

Research output: Contribution to journalArticle

Marcondes, Maria Cecilia G ; Morsey, Brenda ; Emanuel, Katy ; Lamberty, Benjamin G. ; Flynn, Claudia T. ; Fox, Howard S. / CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system. In: Journal of Infectious Diseases. 2015 ; Vol. 211, No. 1. pp. 40-44.
@article{cb1a0de099a3484e8df9784790296cfc,
title = "CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system",
abstract = "Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.",
keywords = "CD8, HIV, SIV, brain, cerebrospinal, immune.",
author = "Marcondes, {Maria Cecilia G} and Brenda Morsey and Katy Emanuel and Lamberty, {Benjamin G.} and Flynn, {Claudia T.} and Fox, {Howard S}",
year = "2015",
month = "1",
day = "1",
doi = "10.1093/infdis/jiu401",
language = "English (US)",
volume = "211",
pages = "40--44",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

AU - Marcondes, Maria Cecilia G

AU - Morsey, Brenda

AU - Emanuel, Katy

AU - Lamberty, Benjamin G.

AU - Flynn, Claudia T.

AU - Fox, Howard S

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

AB - Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

KW - CD8

KW - HIV

KW - SIV

KW - brain

KW - cerebrospinal

KW - immune.

UR - http://www.scopus.com/inward/record.url?scp=84922434257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922434257&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiu401

DO - 10.1093/infdis/jiu401

M3 - Article

VL - 211

SP - 40

EP - 44

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -