CD8 memory T cells

Cross-reactivity and heterologous immunity

Liisa K. Selin, Markus Cornberg, Michael A. Brehm, Sung Kwon Kim, Claudia Calcagno, Dario Ghersi, Roberto Puzone, Franco Celada, Raymond M. Welsh

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.

Original languageEnglish (US)
Pages (from-to)335-347
Number of pages13
JournalSeminars in Immunology
Volume16
Issue number5
DOIs
StatePublished - Jan 1 2004

Fingerprint

Heterologous Immunity
T-Lymphocytes
Immunity
Transplantation Tolerance
Antigens
Aptitude
Viral Tumor Antigens
Graft Survival
Population
Immune System
Maintenance
Viruses

Keywords

  • Allo-reactive
  • Cross-reactive
  • Heterologous immunity
  • Memory T cell
  • Memory attrition

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Selin, L. K., Cornberg, M., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., ... Welsh, R. M. (2004). CD8 memory T cells: Cross-reactivity and heterologous immunity. Seminars in Immunology, 16(5), 335-347. https://doi.org/10.1016/j.smim.2004.08.014

CD8 memory T cells : Cross-reactivity and heterologous immunity. / Selin, Liisa K.; Cornberg, Markus; Brehm, Michael A.; Kim, Sung Kwon; Calcagno, Claudia; Ghersi, Dario; Puzone, Roberto; Celada, Franco; Welsh, Raymond M.

In: Seminars in Immunology, Vol. 16, No. 5, 01.01.2004, p. 335-347.

Research output: Contribution to journalArticle

Selin, LK, Cornberg, M, Brehm, MA, Kim, SK, Calcagno, C, Ghersi, D, Puzone, R, Celada, F & Welsh, RM 2004, 'CD8 memory T cells: Cross-reactivity and heterologous immunity', Seminars in Immunology, vol. 16, no. 5, pp. 335-347. https://doi.org/10.1016/j.smim.2004.08.014
Selin, Liisa K. ; Cornberg, Markus ; Brehm, Michael A. ; Kim, Sung Kwon ; Calcagno, Claudia ; Ghersi, Dario ; Puzone, Roberto ; Celada, Franco ; Welsh, Raymond M. / CD8 memory T cells : Cross-reactivity and heterologous immunity. In: Seminars in Immunology. 2004 ; Vol. 16, No. 5. pp. 335-347.
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